ABSTRACT
The clinical, microscopic, immunohistochemical, and ultrastructural features of three carcinoid tumors of the presacral region are reviewed. All tumors occurred in young women and did not involve the rectum. The predominant microscopic pattern was trabecular. The differential diagnosis included paraganglioma and myxopapillary ependymoma. Immunohistochemically, neuroendocrine markers and low molecular weight cytokeratins were expressed in all cases. Neurosecretory granules were identified in the single case studied by electron microscopy. One case was associated with a tailgut cyst (retrorectal cystic hamartoma). Two patients were treated with complete local excision and are free of disease 3 and 4 years after surgery. One case metastasized to both breasts and recurred locally after an incomplete excision. This report expands the already long list of sites where carcinoid tumors can arise. The frequent association of these tumors with tailgut cysts and their histologic similarities to rectal carcinoid tumors suggest that the most likely derivation of presacral carcinoid tumors is from hindgut rests.
Subject(s)
Carcinoid Tumor/pathology , Sacrococcygeal Region , Adult , Carcinoid Tumor/physiopathology , Carcinoid Tumor/ultrastructure , Female , Humans , Microscopy, ElectronABSTRACT
We report the case of a 71 years old lady with clinical and radiological evidence of colonic obstruction due to diverticulosis. A segmentary resection of the sigmoid colon was performed and the diagnosis of diverticulosis and Crohn's disease was made in the surgical specimen. The patient is doing well and no further extension of the colonic granulomatosis has been found 8 months after surgery. In spite of the great frequency of diverticulosis in the elderly its association with Crohn's disease is quite uncommon. This is probably due to the infrequency of colonic Crohn's disease in this population, particularly of the segmentary type. A few cases of segmentary colonic Crohn's disease that were cured after resection have been published. Even though the postoperative period of our patient is too short for making a good prognosis. Crohn's disease is a chronic relapsing disease and frequency of recurrences is closely related with long term evolution.
Subject(s)
Crohn Disease/complications , Diverticulum, Colon/complications , Intestinal Obstruction/etiology , Aged , Colonic Diseases/etiology , Crohn Disease/pathology , Female , HumansABSTRACT
Se presenta un paciente de sexo femenino, 27 años de edad, con pápulas agminadas y placas de superficie cutánea finamente plegada, distribuídas en forma simétrica en tronco y miembros superiores. La histopatología demostró la ausencia en banda de fibras elásticas en la dermis reticular alta (EDRA). La EDRA es una enfermedad rara, adquirida,idiopatica,sin compromiso sistemico,asintomática,que evoluciona lentamente y se autolimita. Las exposiciones solares pueden intervenir en la patogenia de la afección. Los principales diagnósticos diferenciales a considerar son: cutis laxa y su variante clínica la elastolisis postinflamatoria y cutis laxa; anetodermia; nevo anelástico; y elastolisis perifolicular
Subject(s)
Diagnosis, Differential , Skin Diseases/diagnosis , Elastic Tissue/pathology , Skin Aging/pathology , Sunlight/adverse effectsABSTRACT
Se presenta un paciente de sexo femenino, 27 años de edad, con pápulas agminadas y placas de superficie cutánea finamente plegada, distribuídas en forma simétrica en tronco y miembros superiores. La histopatología demostró la ausencia en banda de fibras elásticas en la dermis reticular alta (EDRA). La EDRA es una enfermedad rara, adquirida,idiopatica,sin compromiso sistemico,asintomática,que evoluciona lentamente y se autolimita. Las exposiciones solares pueden intervenir en la patogenia de la afección. Los principales diagnósticos diferenciales a considerar son: cutis laxa y su variante clínica la elastolisis postinflamatoria y cutis laxa; anetodermia; nevo anelástico; y elastolisis perifolicular(AU)
