ABSTRACT
BACKGROUND: Onychomycosis, a fungal nail infection, can impact quality of life. OBJECTIVE: We sought to evaluate the efficacy and safety of tavaborole topical solution, 5% for treatment of toenail onychomycosis. METHODS: In 2 phase-III trials, adults with distal subungual onychomycosis affecting 20% to 60% of a target great toenail were randomized 2:1 to tavaborole or vehicle once daily for 48 weeks. The primary end point was complete cure of the target great toenail (completely clear nail with negative mycology) at week 52. Secondary end points included completely or almost clear nail, negative mycology, completely or almost clear nail plus negative mycology, and safety. RESULTS: Rates of negative mycology (31.1%-35.9% vs 7.2%-12.2%) and complete cure (6.5% and 9.1% vs 0.5% and 1.5%) significantly favored tavaborole versus vehicle (P ≤ .001). Completely or almost clear nail rates also significantly favored tavaborole versus vehicle (26.1%-27.5% vs 9.3%-14.6%; P < .001). Rates of completely or almost clear nail plus negative mycology (15.3%-17.9% vs 1.5%-3.9%) were significantly greater for tavaborole versus vehicle (P < .001). Application-site reactions with tavaborole included exfoliation (2.7%), erythema (1.6%), and dermatitis (1.3%). LIMITATIONS: Duration of follow-up is a limitation. CONCLUSION: Tavaborole demonstrates a favorable benefit-risk profile in treatment of toenail onychomycosis.
Subject(s)
Antifungal Agents/administration & dosage , Boron Compounds/administration & dosage , Bridged Bicyclo Compounds, Heterocyclic/administration & dosage , Foot Dermatoses/drug therapy , Onychomycosis/drug therapy , Administration, Topical , Adolescent , Adult , Aged , Aged, 80 and over , Antifungal Agents/adverse effects , Boron Compounds/adverse effects , Bridged Bicyclo Compounds, Heterocyclic/adverse effects , Double-Blind Method , Female , Humans , Male , Middle Aged , Young AdultABSTRACT
La dermatitis seborreica es un padecimiento de la piel lampiña y cabelluda, de etiología aún no determinada, Pityrosporum ovale ha sido implicado en su posible patogenia. Se realizó un estudio doble ciego, donde se evaluaron 41 pacientes con dermatitis seborreica, 20 tratados con shampoo de ketoconazol al 0.5 por ciento y 21 con placebo, con control microscópico de P. ovale antes y después del tratamiento. Los resultados mostraron que el ketoconazol al 0.5 fue superior al placebo en el control clínico y micológico de la enfermedad
Subject(s)
Humans , Female , Male , Dermatitis, Seborrheic/therapy , Ketoconazole/administration & dosage , Ketoconazole/therapeutic use , Malassezia/pathogenicityABSTRACT
Los psoralenos son derivados de las furocumarinas, inicialmente obtenidos de los vegetales y posteriormente se han desarrollado sintéticamente. El PUVA es útil en vitiligo, psoriasis, micosis fungoide, liquen plano, urticaria pigmentosa y otras enfermedades. Los psoralenos sintéticos con los que contamos son 8-metoxipsoraleno (8-MOP), el trimetoxipsoralen, el 5-metroxipsoralen (5-MOP). Se ha observado que a pesar de ser tratamientos prolongados, el PUVA es un buen tratamiento para psoriasis y vitiligo, aunque influye mucho la selección del paciente
Subject(s)
Humans , Furocoumarins/pharmacology , Furocoumarins/therapeutic use , In Vitro Techniques , Psoriasis/therapy , PUVA Therapy , PUVA Therapy/instrumentation , Vitiligo/therapyABSTRACT
El itraconazol es un antimicótico sintético de amplio espectro, inhibe la síntesis de ergosterol en la célula fúngica. Es útil en el tratamiento de las dermatomicosis, pitiriasis versicolor, onicomicosis, candidiasis y algunas micosis profundas. Se presenta una revisión, así como esquemas de dosis y nuevas modalidades de tratamiento
