ABSTRACT
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Subject(s)
Humans , Male , Female , Middle Aged , Erdheim-Chester Disease/diagnosis , Erdheim-Chester Disease/drug therapy , Neuroimaging/instrumentation , Neuroimaging/methods , Neuroimaging , Dysarthria/complications , Dysarthria/diagnosis , Interferons/therapeutic use , Imatinib Mesylate/therapeutic use , Cladribine/therapeutic use , Tomography, Emission-Computed/methods , Cerebellar Cortex/pathology , Cerebellar CortexSubject(s)
Erdheim-Chester Disease/physiopathology , Nervous System Diseases/physiopathology , Aged , Diagnosis, Differential , Disease Progression , Erdheim-Chester Disease/complications , Erdheim-Chester Disease/diagnostic imaging , Fatal Outcome , Female , Humans , Magnetic Resonance Imaging , Male , Middle Aged , Nervous System Diseases/diagnostic imaging , Nervous System Diseases/etiology , Tomography, X-Ray ComputedABSTRACT
Analysis of the Careón Unit in the Ordenes Complex (northwest Iberian Massif) has supplied relevant data concerning the existence of a Paleozoic oceanic lithosphere, probably related to the Rheic realm, and the early subduction-related events that were obscured along much of the Variscan belt by subsequent collision tectonics. The ophiolite consists of serpentinized harzburgite and dunite in the lower section and a crustal section made up of coarse-grained and pegmatitic gabbros. An Early Devonian zircon age (395+/-2 Ma, U-Pb) was obtained in a leucocratic gabbro. The whole section was intruded by numerous diabasic gabbro dikes. Convergence processes took place shortly afterward, giving rise to a mantle-rooted synthetic thrust system, with some coeval igneous activity. Garnet amphibolite, developed in metamorphic soles, was found discontinuously attached to the thrust fault. The soles graded downward to epidote-amphibolite facies metabasite and were partially retrogressed to greenschist facies conditions. Thermobarometric estimations carried out at a metamorphic sole (T approximately 650 degrees C; P approximately 11.5 kbar) suggested that imbrications developed in a subduction setting, and regional geology places this subduction in the context of an early Variscan accretionary wedge. Subduction and imbrication of oceanic lithosphere was followed by underthrusting of the Gondwana continental margin.
ABSTRACT
"Adenoma malignum" of the cervix is an extremely rare variant of cervical adenocarcinoma. Its diagnosis by means of light microscopy is rendered very difficult by its strong similarity to benign endocervical hyperplasia. During the last few years immunohistochemistry has proved to be of great help in differential diagnosis. Treatment of "adenoma malignum" also poses great problems. Most cases are diagnosed in advanced stages, although only early diagnosis offers the possibility of effective treatment. Radiotherapy has failed in all known cases in an advanced stage of the disease. Chemotherapy is also not promising as a therapeutical option, because the tumour expresses high levels of the multidrug-resistance marker P-glycoprotein.
