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Food Funct ; 11(7): 6622-6631, 2020 Jul 22.
Article in English | MEDLINE | ID: mdl-32656558

ABSTRACT

Systemic lupus erythematosus (SLE) is a multifactorial autoimmune disease without an effective and safe treatment. Besides, macrophages are the major components of the innate immune system and play a critical role in the inflammation process in SLE. Secoiridoids from olive tree are phenolic compounds which have shown important pharmacological effects. Particularly, oleuropein (OL) has shown antioxidant, anti-inflammatory and immunomodulatory properties suggesting a potential application in a large number of inflammatory and reactive oxygen species (ROS)-mediated diseases. In addition, different studies have shown the importance of acyl derivatives of natural phenols due to their better hydrophilic/lipophilic balance.


Subject(s)
Inflammasomes/metabolism , Iridoid Glucosides/pharmacology , Lupus Erythematosus, Systemic/chemically induced , Lupus Erythematosus, Systemic/drug therapy , Macrophages, Peritoneal/drug effects , NLR Family, Pyrin Domain-Containing 3 Protein/metabolism , Terpenes/adverse effects , Animals , Anti-Inflammatory Agents/pharmacology , Cytokines/metabolism , Iridoids/pharmacology , Lupus Erythematosus, Systemic/pathology , Macrophages/drug effects , Mice , Mice, Inbred BALB C , NLR Family, Pyrin Domain-Containing 3 Protein/genetics , Olea/metabolism , Phenols
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