ABSTRACT
Oxygen uptake of rat brain homogenate was reduced by 1 mM trazodone, a new atypical antidepressant. Na,K-ATPase activity and the associated oxygen consumption of rat brain slices were also reduced. Oxygen consumption of rat brain slices was enhanced by dopamine and this effect was blocked by 0.0001 mM trazodone. This drug uncoupled oxidative phosphorylation.
Subject(s)
Brain/metabolism , Oxygen Consumption/drug effects , Piperazines/pharmacology , Trazodone/pharmacology , Animals , Brain/enzymology , Dopamine/pharmacology , Glucose/metabolism , Male , Mitochondria/drug effects , Mitochondria/metabolism , Oxidative Phosphorylation/drug effects , Rats , Sodium-Potassium-Exchanging ATPase/metabolismABSTRACT
Eleven male chronic alcoholics without cirrhosis but with clinical features of alcoholism were studied. Ten healthy men of similar age served as controls. After suppressing hormone (FSH), luteinizing hormone (LH), 17-beta-oestradiol (E2) and testosterone were determined in basal conditions and after administration of clomiphene citrate in each case. Basal levels of FSH, LH and E2 were higher and the testosterone level lower in the alcoholic group. After stimulation, there was no difference in gonadal hormone levels between both groups, suggesting a normal hypothalamic-pituitary axis with an adequate gonadal response.
