ABSTRACT
PURPOSE: To describe the dynamic changes of the intraocular pressure (IOP) and intracranial pressure (ICP) with normal or pathological values (intracranial hypertension) in nonglaucomatous neurological patients during lumbar punction (LP). METHODS: Case-control study, prospective measurement of tonometry in both groups referred for LP. Intraocular pressure, ICP and translaminar pressure difference (TPD) were compared pre- and post-LP. RESULTS: Thirty-six patients (72 eyes) with mean age of 38.5 (16-64) years and BMI of 26.81 kg/m2 were analysed. The initial mean ICP was 12.81 (± 6.6) mmHg. The mean TPD before and after the LP was 1.48 mmHg and 0.65 mmHg, respectively. The mean IOP of both eyes decreased to 0.8 mmHg post-LP in patients with pathological ICP (p = 0.0193) and normal ICP (p = 0.006). CONCLUSIONS: We found a statistically significant decrease of the IOP post-LP compared to the pre-LP in both groups, being higher in patients with pathological ICP. There were no significant differences of the IOP in patients with normal versus pathological ICP pre-LP/post-LP; neither was found a correlation between ICP and IOP.
Subject(s)
Intracranial Hypertension/physiopathology , Intracranial Pressure/physiology , Intraocular Pressure/physiology , Adolescent , Adult , Case-Control Studies , Female , Follow-Up Studies , Humans , Male , Middle Aged , Prospective Studies , Time Factors , Young AdultABSTRACT
OBJECTIVE: to evaluate vascular involution of corneal neovessels followed by the application of photodynamic therapy (PDT) verteporfirina. METHODS: Prospective, longitudinal, case series. Fifty eyes of 49 candidate patients to partial penetrating keratoplasty (PPK) also called corneal transplant (CT) at risk of corneal neovascularization (CN) of two or more quadrants and which were previous treated with intravenous PDT. The monitoring was carried out with photographic control of the anterior segment assessing adverse effects and development of CN. RESULTS: The length of the CN before and after PDT were 4.39 ± 2.24 vs 3.71 ± 2.48 (p < 0.0001) respectively. This involution was maintained after two months of follow up. One eye (2 %) presented changes Keratometry (keratometric astigmatism). Of the total 45 (90 %) of patients who showed a reduction in the CN, had revascularization within the following six months of intervention. CONCLUSIONS: the PDT with verteporfirina is effective and safe for decreasing the length of the CN, without local and systemic adverse effects. However it is suggested to schedule the surgery two months after to permit revascularization.
