1.
Org Lett
; 24(44): 8093-8097, 2022 11 11.
Article
in English
| MEDLINE
| ID: mdl-36095152
ABSTRACT
A short, modular strategy for synthesizing three representative alkaloids of the (±)-rhazinilam family and 10 non-natural analogs is described. The protocol involves a radical addition/cyclization cascade reaction that assembles the tetrahydroindolizine system decorated with appropriate groups for a subsequent Pd-mediated cyclization, which generates the nine-membered lactam.