Radiosensitivity of L5178Y murine lymphoma cells.

Radiosensitivity of L5178/ murine lymphoma was studied in vivo by means of Co60 pump radiations. The dosage necessary to inactivate these cells was from 5,000 to 6,000 rads applied in an only dose. Doses under 2,000 to 4,000 rads only achieved partial inactivation, proportional to dosage applied. 100 to 1600 rad doses did not produce adverse effects on these cells. Lethal dose for carrier mice was from 800 to 1200 rads applied in one dose only or a total of over 600 rads applied in 100 rad daily sessions. High radioresistance of lymphoma did not allow destruction of all neoplastic cells in vivo for, before this occurred carrier mice died.