ABSTRACT
Congenital pseudarthrosis is a rare disease with variable clinical effects. The disease remains 1 of the most controversial pediatric entities in terms of etiopathogenesis, therapy, and prognosis. Between 0.5% and 2.2% of patients with neurofibromatosis demonstrate pseudarthrosis in any of the long bones. The exact origin of the lesion is even unclear; although several attempts have been made to determine the type of tissue involving the pseudarthrosis site, only fibrous tissue has been documented in different reports. We present 2 unrelated Mexican patients (male and female) with familial neurofibromatosis and congenital pseudarthrosis of the tibia and fibula. Histochemical and immunostain studies after surgical resection of the affected ends from the pseudarthrosis site of both patients showed a picture compatible with hamartoma. This is the first time when histologic evidence of hamartomatous tissue involving the pseudarthrosis site is presented.
Subject(s)
Bone Diseases/congenital , Bone Diseases/pathology , Hamartoma/pathology , Neurofibromatosis 1 , Pseudarthrosis/congenital , Pseudarthrosis/pathology , Biomarkers , Bone Diseases/complications , Female , Fibula/diagnostic imaging , Fibula/pathology , Fibula/surgery , Hamartoma/complications , Hamartoma/surgery , Humans , Immunohistochemistry , Infant , Male , Neurofibromatosis 1/complications , Neurofibromatosis 1/genetics , Neurofibromatosis 1/pathology , Pseudarthrosis/etiology , Radiography , Tibia/diagnostic imaging , Tibia/pathology , Tibia/surgery , Treatment OutcomeABSTRACT
La histoplasmosis, micosis profunda grave, se presenta en México tanto en forma primaria aguda pulmonar, como en forma secundaria crónica-diseminada. La forma primaria pulmonar aguda se presenta principalmente en brotes epidémicos y gracias a ellos ha sido detectada en más de 10 Estados de la República Mexicana. La demostración de H. capsulatum en el suelo de los alrededores de Ciudad Guzmán, Jalisco, exitiende la zona de endemicidad de esta micosis en nuestro país
Subject(s)
Histoplasma/isolation & purification , Soil Microbiology , Soil/analysis , Histoplasmosis/microbiology , MexicoABSTRACT
El presente trabajo describe los resultados de una investigación sobre la frequencia y el tipo de colonización de levaduras en las extremidades inferiores de 62 pacientes diabéticos del Centro Médico de Occidente. La principal levadura aislada fue Candida albicans, en 53% de los cultivos positivos. El sitio de mayor aislamiento fue la región inguinal y no se observó un patrón asociativo entre la frecuencia del aislamiento y la edad
Subject(s)
Humans , Adult , Middle Aged , Candida albicans/isolation & purification , Diabetes Mellitus/microbiology , Perna , GroinABSTRACT
Se presenta el caso de una paciente femenina de 9 años de edad con un ameloblastoma del maxilar superior del subtipo multiquístico o sólido, que requirió una maxilectomía para lograr su extirpación total. No ha presentado recidiva hasta la última revisión 18 meses después de la intervención. Se demuestra en este caso la necesidad de hacer cirugías radicales, en la variedad multiquística de los ameloblastomas, por que de lo contrario las recicidivas son frecuentes
Subject(s)
Child , Humans , Female , Ameloblastoma/surgery , Maxillary Neoplasms/surgeryABSTRACT
The purpose of this study was to investigate the presence of peroxidase (PO) in the histiocytes which are found in the lepromatous lesions of patients with nodular lepromatous leprosy (NLL). We studied dermoepidermal biopsy specimens from lepromstous lesions and blood smears of 10 patients with NLL, eight males and twoo females 28 to 63 years age (average 45 + or - 6.2), of which nine coursed with the stable form of the disease and one was in lepromatous reaction. Six had received treatment with diaminodiphenylsulphone for more than six months, and the other four, none. As controls we studied the blood smears of 10 healthy controls and 10 rat liver sections. PO was investigated in histiocytes, Kupffer cells and polymorphonuclears by dichlorhydrate oxydation, according to the technique of Kaplow. By means of Fite-Faraco´s stain, all ten cases proved to have abundant phagocytized M. leprae. PO was not found in histiocytes of lepromatous lesions in nine cases of stable NLL in lepromatous reaction. PO was present in Kupffer cells, in polymorphonuclears of patients with NLL and in controls. No difference was found either in the PO or M. leprae contents between treated and untreated patients. The PO deficiency in histiocytes of patients with NLL may be related to an incapacity of these cells to destroy M. leprae.
