Prevalence of Chronic Pain by Immigration Status and Latino Ethnicity.

OBJECTIVE: The goal of this study was to evaluate the Latino paradox and healthy migrant hypotheses by estimating the association between the prevalence of chronic pain, immigration status, and Latino ethnicity. METHODS: This cross-sectional study analyzed pooled data from 85,395 adult participants of the 2019-2021 National Health Interview Survey. The dependent variables were any pain and chronic pain in the past 3 months. The independent variables were immigration status (US born, naturalized citizen, non-citizen) and Latino ethnicity. RESULTS: Chronic pain was prevalent for nearly a quarter of US born non-Latino adults (24%) and non-citizen non-Latino adults had the lowest prevalence at 8%. In multivariable adjusted models, US born non-Latino immigration status and ethnicity was associated with a higher probability of reporting chronic pain in the last 3 months compared to US born Latino adults (-3.0%; 95% CI = -4.4%, -1.6%), naturalized citizen non-Latino adults (-4.7%; 95% CI = -5.9%, -3.4%), naturalized citizen Latino adults (-6.7%; 95% CI = -8.5%, -4.9%), non-citizen non-Latino adults (-3.1%; 95% CI = -4.7%, -1.5%), and non-citizen Latino adults (-8.9%; 95% CI = -10.8%, -7.0%). CONCLUSION: US Born non-Latino adults reported the highest prevalence of chronic pain and non-citizen Latino adults reported the lowest prevalence of chronic pain providing support for the Latino paradox and healthy migrant effect hypotheses.

Health Care Access and Utilization and the Latino Health Paradox.

BACKGROUND: The Latino health paradox is the phenomenon whereby recent Latino immigrants have, on average, better health outcomes on some indicators than Latino immigrants who have lived in the United States longer and US-born Latinos and non-Latino Whites. This study examined whether the paradox holds after accounting for health care access and utilization. METHODS: The 2019-2020 National Health Interview Survey data were used. The main predictors included population groups of foreign-born and US-born Latinos (Mexican or non-Mexican) versus US-born non-Latino Whites. Predicted probabilities of health outcomes (self-reported poor/fair health, overweight/obesity, hypertension, coronary heart disease, diabetes, cancer, and depression) were calculated and stratified by length of residence in the United States (<15 or ≥15 years) among foreign-born Latinos and sex (female or male). Multivariable analyses adjusted for having a usual source of care other than the emergency department, health insurance, a doctor visit in the past 12 months, predisposing and enabling factors, and survey year. RESULTS: After adjusting for health care access, utilization, and predisposing and enabling factors, foreign-born Latinos, including those living in the United States ≥15 years, had lower predicted probabilities for most health outcomes than US-born non-Latino Whites, except overweight/obesity and diabetes. US-born Latinos had higher predicted probabilities of overweight/obesity and diabetes and a lower predicted probability of depression than US-born non-Latino Whites. CONCLUSIONS: In this national survey, the Latino health paradox was observed after adjusting for health care access and utilization and predisposing and enabling factors, suggesting that, although these are important factors for good health, they do not necessarily explain the paradox.

Black carbon in urban soils: land use and climate drive variation at the surface.

BACKGROUND: Black carbon (BC) encompasses a range of carbonaceous materials--including soot, char, and charcoal--derived from the incomplete combustion of fossil fuels and biomass. Urban soils can become enriched in BC due to proximity to these combustion sources. We conducted a literature review of BC in urban soils globally and found 26 studies reporting BC and total organic carbon (TOC) content collected to a maximum of 578 cm depth in urban soils across 35 cities and 10 countries. We recorded data on city, climate, and land use/land cover characteristics to examine drivers of BC content and contribution to TOC in soil. RESULTS: All studies were conducted in the northern hemisphere, with 68% of the data points collected in China and the United States. Surface samples (0-20 cm) accounted for 62% of samples in the dataset. Therefore, we focused our analysis on 0-10 cm and 10-20 cm depths. Urban soil BC content ranged from 0-124 mg/g (median = 3 mg/g) at 0-10 cm and from 0-53 mg/g (median = 2.8 mg/g) at 10-20 cm depth. The median proportional contribution of BC to TOC was 23% and 15% at 0-10 cm and 10-20 cm, respectively. Surface soils sampled in industrial land use and near roads had the highest BC contents and proportions, whereas samples from residential sites had among the lowest. Soil BC content decreased with mean annual soil temperature. CONCLUSIONS: Our review indicates that BC comprises a major fraction (nearly one quarter) of the TOC in urban surface soils, yet sampling bias towards the surface could hide the potential for BC storage at depth. Land use emerged as an importer driver of soil BC contents and proportions, whereas land cover effects remain uncertain. Warmer and wetter soils were found to have lower soil BC than cooler and drier soils, differences that likely reflect soil BC loss mechanisms. Additional research on urban soil BC at depth and from diverse climates is critical to better understand the role of cities in the global carbon cycle.

Satellite-based aerosol optical depth estimates over the continental U.S. during the 2020 wildfire season: Roles of smoke and land cover.

Wildfires produce smoke that can affect an area >1000 times the burn extent, with far-reaching human health, ecologic, and economic impacts. Accurately estimating aerosol load within smoke plumes is therefore crucial for understanding and mitigating these impacts. We evaluated the effectiveness of the latest Collection 6.1 MODIS Multi-Angle Implementation of Atmospheric Correction (MAIAC) algorithm in estimating aerosol optical depth (AOD) across the U.S. during the historic 2020 wildfire season. We compared satellite-based MAIAC AOD to ground-based AERONET AOD measurements during no-, light-, medium-, and heavy-smoke conditions identified using the Hazard Mapping System Fire and Smoke Product. This smoke product consists of maximum extent smoke polygons digitized by analysts using visible band imagery and classified according to smoke density. We also examined the strength of the correlations between satellite- and ground-based AOD for major land cover types under various smoke density levels. MAIAC performed well in estimating AOD during smoke-affected conditions. Correlations between MAIAC and AERONET AOD were strong for medium- (r = 0.91) and heavy-smoke (r = 0.90) density, and MAIAC estimates of AOD showed little bias relative to ground-based AERONET measurements (normalized mean bias = 3 % for medium, 5 % for heavy smoke). During two high AOD, heavy smoke episodes, MAIAC underestimated ground-based AERONET AOD under mixed aerosol (i.e., smoke and dust; median bias = -0.08) and overestimated AOD under smoke-dominated (median bias = 0.02) aerosol. MAIAC most overestimated ground-based AERONET AOD over barren land (mean NMB = 48 %). Our findings indicate that MODIS MAIAC can provide robust estimates of AOD as smoke density increases in coming years. Increased frequency of mixed aerosol and expansion of developed land could affect the performance of the MAIAC algorithm in the future, however, with implications for evaluating wildfire-associated health and welfare effects and air quality standards.

Soil Black Carbon Increases Under Urban Trees with Road Density and Time: Opportunity Hotspots for Carbon Storage in Urban Ecosystems.

Black carbon (BC) can comprise a significant fraction of the soil carbon pool in cities. However, vegetation cover and human activity influence the spatial distribution of urban soil BC. We quantified soil total carbon (TC), soil organic carbon (SOC), BC, and total nitrogen (TN) in a medium-sized city in Dallas-Fort Worth, Texas. Soils were sampled to 20 cm depth from underneath 16 paired Quercus stellata (post oak) trees and open lawns. Effects of vegetation cover, road density, and building age (a proxy for time since development) on soil C and N were analyzed. Soil OC concentrations were higher under post oak trees (5.5%) compared to open lawns (3.6%) at 0-10 cm, but not at 10-20 cm depth. In contrast, soil BC and TN did not differ by vegetation cover. There were significant interaction effects between vegetation cover and road density and vegetation cover and building age on soil BC. At 0-10 cm, soil BC concentrations, stock, and BC/SOC ratios increased more with road density under trees than lawns, indicating enhanced atmospheric BC deposition to tree canopies. Black carbon in tree soils also increased with building age as compared to lawn soils, likely due to higher BC retention under trees, enhanced BC losses under lawns, or both. Our findings show that urban tree soils are localized opportunity hotspots for BC storage in areas with elevated emissions and longer time since development. Conserving and planting urban trees above permeable surfaces and soils could contribute to long-term carbon storage in urban ecosystems.

Shower thoughts: why scientists should spend more time in the rain.

Stormwater is a vital resource and dynamic driver of terrestrial ecosystem processes. However, processes controlling interactions during and shortly after storms are often poorly seen and poorly sensed when direct observations are substituted with technological ones. We discuss how human observations complement technological ones and the benefits of scientists spending more time in the storm. Human observation can reveal ephemeral storm-related phenomena such as biogeochemical hot moments, organismal responses, and sedimentary processes that can then be explored in greater resolution using sensors and virtual experiments. Storm-related phenomena trigger lasting, oversized impacts on hydrologic and biogeochemical processes, organismal traits or functions, and ecosystem services at all scales. We provide examples of phenomena in forests, across disciplines and scales, that have been overlooked in past research to inspire mindful, holistic observation of ecosystems during storms. We conclude that technological observations alone are insufficient to trace the process complexity and unpredictability of fleeting biogeochemical or ecological events without the shower thoughts produced by scientists' human sensory and cognitive systems during storms.

Trends in Routine Checkup Within the Past Year Following a Hurricane.

The goal of this nationally representative, cross-sectional study is to evaluate the trends in routine checkup within the last year associated with exposure to a hurricane. We compared Puerto Rico (2017 Hurricane Irma, Hurricane Maria), Texas (2017 Hurricane Harvey), and Florida (2017 Hurricane Irma, Hurricane 2018 Michael) with states that had a category 1-2 hurricane make landfall from 2014 to 2019: Georgia, Louisiana, Mississippi, North Carolina, and South Carolina. We found that states impacted by a major hurricane in 2017 had a drop in routine checkup while the states that experienced a category 1-2 landfall did have a change in that year. By the following year, all states reported an increase in routine checkup suggesting that the disruption in routine care was temporary.

Análisis de la Ley de Eutanasia Española: logros e inconsistencias de la asistencia jurídica al morir / Anàlisi de la Llei d'Eutanàsia Espanyola: assoliments i inconsistències de l'assistència jurídica en morir / Analyzing the Spanish Euthanasia Law: Achievements andinconsistencies of the legal assistance to die

The Spanish government recently passed legislation that legalized euthanasia. This article analyzes the Organic Law on the Regulation of Voluntary Euthanasia by exploring its procedural aspects, the various methods of providing assistance to die and the medical role under the law. After thisexamination, the article points out three potential problems with respect to the law’s practical implementation. The first potential problem is the lack of explicit regulation regarding the assistance to die as provided to patients with mental disorders. Second, the law is unclear concerning the permissible extent of the legal assistance to die for patients self-administrating the lethal drug. Third, the ambiguous role assigned to medical staff during the final phases of euthanasia, especially concerning the duty of “observation and support”. This study concludes that the new law, despite its proponents’ thorough effort to guarantee the right to receive euthanasia, contains significant loopholes that may generate future controversies.(AU)

El govern espanyol va aprovar recentment una llei que va legalitzar l'eutanàsia. Aquest article analitza la Llei Orgànica de Regulació de l'Eutanàsia Voluntària explorant-ne els aspectes processals, les diverses modalitats d'assistència en morir i la funció mèdica prevista a la llei. Després d’aquest examen, l’article assenyala tres problemes potencials pel que fa a la implementació pràctica de la llei. El primer problema potencial és la manca d'una regulació explícita sobre l'assistència a la mort que es brinda als pacients amb trastorns mentals. En segon lloc, la llei no és clara respecte a l'abast permissible de l'assistència legal per morir per als pacients que s'autoadministren la droga letal. En tercer lloc, el paper ambigu assignat al personal mèdic durant les fases finals de l'eutanàsia, especialment pel que fa al deure “observació i suport”. Aquest estudi conclou que la nova llei, malgrat l'esforç ardu dels seus impulsors per garantir el dret a rebre l'eutanàsia, conté importants llacunes que poden generar futures controvèrsies.(AU)

El gobierno español aprobó recientemente una ley que legalizó la eutanasia. Este artículo analiza la Ley Orgánica de Regulación de la Eutanasia Voluntaria explorando sus aspectos procesales, las diversas modalidades de asistencia al morir y la función médica prevista en la ley. Luego de este examen, el artículo señala tres problemas potenciales con respecto a la implementación práctica de la ley. El primer problema potencial es la falta de una regulación explícita sobre la asistencia a la muerte que se brinda a los pacientes con trastornos mentales. En segundo lugar, la ley no es clara con respecto al alcance permisible de la asistencia legal para morir para los pacientes que se autoadministran la droga letal. En tercer lugar, el papel ambiguo asignado al personal médico durante las fases finales de la eutanasia, especialmente en lo que se refiere al deber de “observación y apoyo”. Este estudio concluye que la nueva ley, a pesar del arduo esfuerzo de sus impulsores por garantizar el derecho a recibir la eutanasia, contiene importantes lagunas que pueden generar futuras controversias.(AU)

Undocumented Latino Immigrants and the Latino Health Paradox.

INTRODUCTION: Despite having worse healthcare access and other social disadvantages, immigrants have, on average, better health outcomes than U.S.-born individuals. For Latino immigrants, this is known as the Latino health paradox. It is unknown whether this phenomenon applies to undocumented immigrants. METHODS: This study used restricted California Health Interview Survey data from 2015 to 2020. Data were analyzed to test the relationships between citizenship/documentation status and physical and mental health among Latinos and U.S.-born Whites. Analyses were stratified by sex (male/female) and length of U.S. residence (<15 years/>= 15 years). RESULTS: Undocumented Latino immigrants had lower predicted probabilities of reporting any health condition, asthma, and serious psychological distress and had a higher probability of overweight/obesity than U.S.-born Whites. Despite having a higher probability of overweight/obesity, undocumented Latino immigrants did not have probabilities of reporting diabetes, high blood pressure, or heart disease different from those of U.S.-born Whites after adjusting for having a usual source of care. Undocumented Latina women had a lower predicted probability of reporting any health condition and a higher predicted probability of overweight/obesity than U.S.-born White women. Undocumented Latino men had a lower predicted probability of reporting serious psychological distress than U.S.-born White men. There were no differences in outcomes when comparing shorter- with longer-duration undocumented Latino immigrants. CONCLUSIONS: This study observed that the Latino health paradox may express patterns for undocumented Latino immigrants that are different from those for other Latino immigrant groups, emphasizing the importance of accounting for documentation status when conducting research on this population.

Growing inequities in mental health crisis services offered to indigent patients in Puerto Rico versus the US states before and after Hurricanes Maria and Irma.

OBJECTIVE: To assess changes in the availability of mental health crisis services in Puerto Rico relative to US states before and after Hurricanes Maria and Irma. DATA SOURCES/STUDY SETTING: National Mental Health Services Surveys conducted in 2016 and 2020. STUDY DESIGN: Repeated cross-sectional design. The independent variable was mental health facility location in Puerto Rico or a US state. Dependent variables were the availability of three mental health crisis services (psychiatric emergency walk-in services, suicide prevention services, and crisis intervention team services). DATA COLLECTION/EXTRACTION METHODS: The proportion and per 100,000 population rate of facilities offering crisis services were calculated. PRINCIPAL FINDINGS: The availability of crisis services at mental health facilities in Puerto Rico remained stable between 2016 and 2020. These services were offered less at indigent care facilities in Puerto Rico than US states (e.g., 38.2% vs. 49.5% for suicide prevention, p = 0.06) and the magnitude of difference increased following Hurricane Maria. CONCLUSIONS: There are disparities between Puerto Rico and US states in the availability of mental health crisis services for indigent patients.

Urban edge trees: Urban form and meteorology drive elemental carbon deposition to canopies and soils.

Urban tree canopies are a significant sink for atmospheric elemental carbon (EC)--an air pollutant that is a powerful climate-forcing agent and threat to human health. Understanding what controls EC deposition to urban trees is therefore important for evaluating the potential role of vegetation in air pollution mitigation strategies. We estimated wet, dry, and throughfall EC deposition for oak trees at 53 sites in Denton, TX. Spatial data and airborne discrete-return LiDAR were used to compute predictors of EC deposition, including urban form characteristics, and meteorologic and topographic factors. Dry and throughfall EC deposition varied 14-fold across this urban ecosystem and exhibited significant variability from spring to fall. Generalized additive modeling and multiple linear regression analyses showed that urban form strongly influenced tree-scale variability in dry EC deposition: traffic count as well as road length and building height within 100-150 m of trees were positively related to leaf-scale dry deposition. Rainfall amount and extreme wind-driven rain from the direction of major pollution sources were significant drivers of throughfall EC. Our findings indicate that complex configurations of roads, buildings, and vegetation produce "urban edge trees" that contribute to heterogeneous EC deposition patterns across urban systems, with implications for greenspace planning.

The impact of Medicaid funding structures on inequities in health care access for Latinos in New York, Florida, and Puerto Rico.

OBJECTIVE: To study the impact of Medicaid funding structures before and after the implementation of the Affordable Care Act (ACA) on health care access for Latinos in New York (Medicaid expansion), Florida (Medicaid non-expansion), and Puerto Rico (Medicaid block grant). DATA SOURCES: Pooled state-level data for New York, Florida, and Puerto Rico from the 2011-2019 Behavioral Risk Factor Surveillance System and data from the 2011-2019 American Community Survey and Puerto Rico Community Survey. STUDY DESIGN: Cross-sectional study using probit with predicted margins to separately compare four health care access measures among Latinos in New York, Florida, and Puerto Rico (having health insurance coverage, having a personal doctor, delayed care due to cost, and having a routine checkup). We also used difference-in-differences to measure the probability percent change of having any health insurance and any public health insurance before (2011-2013) and after (2014-2019) the ACA implementation among citizen Latinos in low-income households. DATA COLLECTION: The sample consisted of Latinos aged 18-64 residing in New York, Florida, and Puerto Rico from 2011 to 2019. PRINCIPAL FINDINGS: Latinos in Florida had the lowest probability of having health care access across all four measures and all time periods compared with those in New York and Puerto Rico. While Latinos in Puerto Rico had greater overall health care access compared with Latinos in both states, health care access in Puerto Rico did not change over time. Among citizen Latinos in low-income households, New York had the greatest post-ACA probability of having any health insurance and any public health insurance, with a growing disparity with Puerto Rico (9.7% any [1.6 SE], 5.2% public [1.8 SE]). CONCLUSIONS: Limited Medicaid eligibility (non-expansion of Florida's Medicaid program) and capped Medicaid funds (Puerto Rico's Medicaid block grant) contributed to reduced health care access over time, particularly for citizen Latinos in low-income households.

Wet nitrogen (N) deposition to urban Latin America: filling in the gaps with GEOS-Chem.

In Latin America, atmospheric deposition is a major vector of nitrogen (N) input to urban systems. Yet, measurements of N deposition are sparse, precluding analysis of spatial patterns, temporal trends, and ecosystem impacts. Chemical transport models can be used to fill these gaps in the absence of dense measurements. Here, we evaluate the performance of a global 3-D chemical transport model in simulating spatial and interannual variation in wet inorganic N (NH4-N + NO3-N) deposition across urban areas in Latin America. Monthly wet and dry inorganic N deposition to Latin America were simulated for the period 2006-2010 using the GEOS-Chem Chemical Transport Model. Published estimates of observed wet or bulk inorganic N deposition measured between 2006-2010 were compiled for 16 urban areas and then compared with model output from GEOS-Chem. Observed mean annual inorganic N deposition to the urban study sites ranged from 5.7-14.2 kg ha-1 yr-1, with NH4-N comprising 48-90% of the total. Results show that simulated N deposition was highly correlated with observed N deposition across sites (R2 = 0.83, NMB = -50%). However, GEOS-Chem generally underestimated N deposition to urban areas in Latin America compared to observations. Underestimation due to bulk sampler dry deposition artifacts was considered and improved bias without improving correlation. In contrast to spatial variation, the model did not capture year-to-year variation well. Discrepancies between modeled and observed values exist, in part, because of uncertainties in Latin American N emissions inventories. Our findings indicate that even at coarse spatial resolution, GEOS-Chem can be used to simulate N deposition to urban Latin America, improving understanding of regional deposition patterns and potential ecological effects.

Influence of sharpening filters on the detection of root fractures using low-dose cone-beam computed tomography.

OBJECTIVES: To evaluate the influence of sharpening filters in the detection of root fractures using low-dose cone-beam computed tomography (CBCT). MATERIALS AND METHODS: Eighty-four CBCT volumes acquired at three mA levels of 28 teeth inserted in the dental socket of dry human skull were selected from a previous study. The teeth were divided into four groups according to the presence and absence of root fracture and endodontic filling. Five radiologists evaluated all CBCT volumes for the presence of root fracture with and without the application of "Sharpen 1x" and "Sharpen 2x" filters in OnDemand3D software. Area under the ROC curve (AUC), sensitivity, specificity, and inter- and intra-observer concordance were calculated and compared (α = 0.05). RESULTS: Sharpening filters did not lead to significant differences in AUC, sensitivity, and specificity at the three mA levels tested (p > 0.05), regardless of the presence of endodontic filling (p > 0.05). However, the significant reduction of AUC observed in CBCT volumes at 4 mA without filter (p < 0.05) ceased to exist after the application of filters (p > 0.05). Sensitivity and specificity ranged from low and moderate. CONCLUSIONS: The use of sharpening filters can be recommended in CBCT volumes at 4 mA for root fracture detection for leading to the same performance as those at 6.3 and 10 mA. The presence of endodontic filling material did not influence the action of filters in the diagnosis of root fracture. CLINICAL RELEVANCE: Sharpening filters seem to contribute to the diagnosis of root fracture in CBCT volumes acquired with reduced radiation dose.

The Other US Border: Health Insurance Coverage Among Latino Immigrants In Puerto Rico.

Puerto Rico is a US territory and a popular destination for Latino immigrants in the Caribbean. Even with few language and cultural barriers, however, many Latino immigrants in Puerto Rico are uninsured. Using data from the 2014-19 Puerto Rico Community Survey, we examined inequities in health insurance coverage for non-Puerto Rican Latinos ages 18-64 living in Puerto Rico according to citizenship status and Latino subgroup (Dominican, Cuban, Mexican, and other Latino). After controlling for potential confounders, we found that noncitizen Dominicans had a significantly lower probability of having any health insurance (57.2 percent) and having any private insurance (31.5 percent). Regardless of similarities in culture and language, Latino immigrants on the island, particularly Dominicans, experience major health insurance coverage inequities. Considering that Puerto Rico's immigration system is regulated by US federal statute, both federal and local policy makers should acknowledge and focus on reducing these immigrant disparities in health insurance coverage.

Ambient urban N deposition drives increased biomass and total plant N in two native prairie grass species in the U.S. Southern Great Plains.

Remnants of native tallgrass prairie experience elevated atmospheric nitrogen (N) deposition in urban areas, with potential effects on species traits that are important for N cycling and species composition. We quantified bulk (primarily wet) inorganic N (NH4+-N + NO3--N) deposition at six sites along an urban development gradient (6-64% urban) in the Dallas-Fort Worth metropolitan area from April 2014 to October 2015. In addition, we conducted a phytometer experiment with two common native prairie bunchgrass species--one well studied (Schizachyrium scoparium) and one little studied (Nasella leucotricha)--to investigate ambient N deposition effects on plant biomass and tissue quality. Bulk inorganic N deposition ranged from 6.1-9.9 kg ha-1 yr-1, peaked in spring, and did not vary consistently with proportion of urban land within 10 km of the sites. Total (wet + dry) inorganic N deposition estimated using bulk deposition measured in this study and modeled dry deposition was 12.9-18.2 kg ha-1 yr-1. Although the two plant species studied differ in photosynthetic pathway, biomass, and tissue N, they exhibited a maximum 2-3-fold and 2-4-fold increase in total biomass and total plant N, respectively, with 1.6-fold higher bulk N deposition. In addition, our findings indicate that while native prairie grasses may exhibit a positive biomass response to increased N deposition up to ~18 kg ha-1 yr-1, total inorganic N deposition is well above the estimated critical load for herbaceous plant species richness in the tallgrass prairie of the Great Plains ecoregion and thus may negatively affect these plant communities.

Neoadjuvant immunotherapy in resectable head and neck cancer: oral cavity carcinoma as a potential research model.

Squamous cell carcinoma of oral cavity (OCSCC) accounts for approximately 25% of cases of head and neck squamous cell carcinoma (HNSCC). Tobacco and alcohol consumption are the main risk factors for both cancers. Surgical resection, combined with adjuvant radiotherapy or radiochemotherapy in patients with high risk of relapse, is the key element in management in the initial stages. However, despite the availability of aggressive multidisciplinary treatments, advanced resectable OCSCC carries poor prognosis; only half of the patients are disease-free 5 years after the surgery. Immunotherapy based on the use of immune checkpoint inhibitors has been proven to be effective in a wide variety of tumours, including recurrent and metastatic HNSCC. These positive results resulted in investigations into its effectiveness in earlier stages of the disease with OCSCC emerging as an interesting research model because of the accessible location of the tumours. This article reviews the potential advantages of emerging immunotherapeutic agents [mainly monoclonal antibodies against programmed cell death-1 (PD-1) immune checkpoint inhibitors] as neoadjuvant treatment for OCSCC at locoregional stages as well as the ongoing clinical trials, challenges in evaluating tumour response, and possible predictive biomarkers of response with highlights regarding the role of oral microbiota as modulators of immune response. The efficacy and safety of anti-PD-1 drugs in these patients have been proven in preliminary trials. If there is a decrease in the relapse rate and an improvement in the overall survival after surgical resection in ongoing trials, preoperative immunotherapy may be established as a treatment option for patients with early stages of the disease.

Bird feathers are potential biomonitors for airborne elemental carbon.

Birds can serve as effective biomonitors of air pollution, yet few studies have quantified external particulate matter accumulation on bird feathers. Biomonitoring of airborne elemental carbon (EC) is of critical significance because EC is a component of particulate matter with adverse effects on air quality and human health. To assess their effectiveness for use in EC monitoring, we compared EC accumulation on bird feathers at two sites that differed in vehicular traffic volume in an urban environment within the Dallas-Fort Worth Metropolitan Area, USA. Moulted flight feathers from domestic chickens were experimentally exposed to ambient EC pollution for 5 days in two urban microenvironments 1.5 km distant from each other that differed in traffic volume--adjacent to an interstate highway and a university campus bus stop. Feathers near the highway accumulated approximately eight times more EC (307 ± 34 µg m-2 day-1), on average, than feathers near the bus stop (40 ± 9 µg m-2 day-1). These findings indicate that EC accumulation on feathers varies over short distances within urban areas and that bird feathers potentially can be used for biomonitoring airborne EC.

Uso de ivermectina en pacientes con la COVID-19: Una revision narrativa / Use of ivermectin in patients with covid-19: A narrative review

Introducción. Hacia finales del último mes del 2019, se identificó un nuevo coronavirus altamente contagioso en China provocando el inicio de una nueva pandemia. Millones de infectados y miles de muertes es el resultado de la infección por el SARS-CoV-2; diferentes estrategias terapéuticas se han propuesto para su tratamiento, una de ellas ha sido la ivermectina, provocando discrepancias en la comunidad médica en relación a su uso. Nos propusimos revisar la evidencia científica disponible sobre el uso de la ivermectina en el contexto de la COVID-19 en humanos. Se realizó una búsqueda de bibliografía en las siguientes bases de datos: Pub Med, Web of Science, Cochrane, Clinical Trials e ISRCCTN usando expresiones de búsqueda que incluyan los siguientes términos: ivermectina, antiviral, virus, covid-19 y/o SARS-CoV-2. No hay evidencia científica que respalde el uso de ivermectina como tratamiento y/o profilaxis para la infección por SARS COV-2.

Introduction. Towards the end of the last month of 2019, a new highly contagious coronavirus was identified in China causing the start of a new pandemic. Millions of infected people and thousands of deaths are the result of SARS-CoV-2 infection; different therapeutic strategies have been proposed for its treatment, one of them has been ivermectin, causing discrepancies in the medical community regarding its use. We set out to review the available scientific evidence on the use of ivermectin in the context of IDVC-19 in humans. A literature search was conducted on the following databases: Pub Med, Web of Science, Cochrane, Clinical Trials, and ISRCCTN using search expressions that include the following terms: ivermectin, antiviral, virus, covid-19 and/or SARS-CoV- 2. There is no scientific evidence to support the use of ivermectin as a treatment and/or prophylaxis for SARSCoV- 2 infection.