Duodenal gangliosidosis in a cat: ultrastructural study.

Ultrastructural changes similar to those seen in gangliosidosis in man were detected in the duodenal mucosa of a cat (cat 1). The N-acetylneuraminic acid concentration was determined from the duodenum of cat 1 and from a clinically normal cat (cat 2). The total amount of gangliosides in the duodenum of cat 1 was 100 times greater than in the duodenum of cat 2 per unit wet weight. The lyophilizate from the intestines of both cats gave a blue-violet color that was regarded as qualitatively positive for N-acetylneuraminic acid determination. In cat 1, membranous cytoplasmic bodies were in all cell types of the duodenal mucosa.

[Distribution of a cell with intracytoplasmic crystal and crystaloid material in the small and large intestine of the rat and mouse]. / Distribución de una célula con material cristaloide o cristales intracitoplásmicos en el intestino delgado y grueso de la rata y del ratón

In suckling and adult rats, distribution in the small and large intestine of crystal-like containing cell was studied and was compared with that of crystal containing cell in the mouse. In the former, cell predominates in cecum and in the latter in the ileum. Numerical differences were statistical significant. It was postulated that these cells might be different. Up to date, they have been regarded as the same cell by other authors and are known as globular leucocyte.