ABSTRACT
In 1858 Dr. Brown-Séquard arrived in London. During his stay there, he was appointed physician at the National Hospital for the Paralysed and Epileptic (now the National Hospital), and was elected Fellow of the Royal College of Physician's of London, as well as Fellow of the Royal society. During this time he also published his 'Course of Lectures on the Physiology and Pathology of the Central Nervous System' an early exposition of what is now know as 'his' syndrome. During his time in London, Dr. Brown-Séquard made many well-known acquaintances, amongst others Charles Darwin, T.H. Huxley, and Louis Pasteur. Three years after his appointment as physician at the National Hospital, he left London. Increasingly, he was to abondon fashionable practice to concentrate on his study of what are now known as the endocrinal glands. In this way, he became a pioneer of the study of endocrinology.
Subject(s)
Endocrinology/history , Neurology/history , Endocrine Glands , History, 19th Century , United KingdomSubject(s)
Endocrinology/history , France , History, 19th Century , History, 20th Century , Humans , Male , Neurology/history , United Kingdom , United StatesSubject(s)
Aging , Brain/physiopathology , Politics , Social Responsibility , Age Factors , Aged , Female , Humans , Male , RetirementABSTRACT
Three members of a family were affected by an autosomal dominant disorder comprising cerebellar ataxia, sensorineural deafness, myoclonus, and peripheral neuropathy. This is the second kindred with this syndrome reported to date. Necropsy of the proband showed loss of cells in the dentate nuclei, a reduced amount of cerebellar white matter, and pallor of the gracile tracts in the spinal cord.
Subject(s)
Cerebellar Ataxia/genetics , Chromosome Aberrations/genetics , Deafness/genetics , Epilepsies, Myoclonic/genetics , Peripheral Nervous System Diseases/genetics , Adult , Aged , Brain/pathology , Cerebellar Ataxia/pathology , Chromosome Aberrations/pathology , Chromosome Disorders , Deafness/pathology , Epilepsies, Myoclonic/pathology , Female , Genes, Dominant , Humans , Male , Middle Aged , Neural Pathways/pathology , Neurons/ultrastructure , Pedigree , Peripheral Nervous System Diseases/pathology , Spinal Cord/pathologySubject(s)
Decision Making , Leadership , Mental Disorders , Dementia/etiology , Health Status , Humans , Mental Disorders/etiologyABSTRACT
The case of a left handed girl aged 18 years suffering from the "epidermal maevus syndrome" is described. She presented with dysphasia, transient left hemiparesis, and sensory symptoms due to an occlusion of the right internal carotid artery. Arterial occlusion, abnormal retinal vessels, and Raynaud's phenomenon have not been previously documented. The neurological complications of this syndrome are discussed. It is suggested that the arterial occlusion may have been caused by a dysplastic artery.
