Subject(s)
Lupus Erythematosus, Discoid/radiotherapy , Ultraviolet Therapy/methods , Adult , Female , Humans , Middle Aged , Treatment OutcomeABSTRACT
We examined the responsiveness of cultured dermal fibroblasts from biopsies of 6 patients with active morphoea and a similar number of matched controls to the cell proliferation inhibition activity of calcipotriol. Cultured fibroblasts from controls showed no significant response to calcipotriol (at concentrations of 1 x 10(-8) to 1 x 10(-4) M). However, calcipotriol did inhibit the proliferation response of morphoea fibroblasts at all concentrations when compared with controls. There was 4- to 20-fold inhibition in 2 of the morphoea patients when compared with control samples. Four other morphoea samples showed inhibition but to a lesser extent compared with controls.
Subject(s)
Calcitriol/analogs & derivatives , Dermatologic Agents/pharmacology , Fibroblasts/drug effects , Scleroderma, Localized/physiopathology , Adolescent , Adult , Biopsy , Calcitriol/pharmacology , Case-Control Studies , Cell Division/drug effects , Cells, Cultured , Female , Humans , Male , Middle Aged , Scleroderma, Localized/pathologyABSTRACT
Three cases of chondrodermatitis nodularis helicis (CDNH) in patients with the limited form of systemic sclerosis are described. Two of the three cases were noted during regular follow-up visits and the third case was found as part of a survey of the 21 other patients with systemic sclerosis routinely seen in the department. While CDNH is known to have several predisposing causes there are no reports in the literature of this condition occurring in association with systemic sclerosis.
