Ethnoracialized group differences in attitudes and knowledge about schizophrenia and willingness to engage in biomarker research: The UBIGR Study.

Although there is renewed optimism in biomarker research in schizophrenia, there is also need for greater inclusion of historically underrepresented groups in the research. In the present study, we surveyed 599 African American, 352 American Indian/Alaska Native, and 725 NonHispanic White participants about their attitudes toward research, knowledge and attitudes about schizophrenia, and willingness to engage in biomarker testing. Attitudes toward research were examined using the standardized 7-item Research Attitudes Questionnaire (RAQ) measure. Using structural equation modeling (SEM), we tested our predictive model of the likelihood of willingness to engage in biomarker testing for schizophrenia risk. Members of historically underrepresented groups were less willing to engage in biomarker testing. Overall, attitudes toward research, particularly trust, influenced biomarker testing willingness. These findings suggest that factors influencing willingness to engage in schizophrenia biomarker testing may be modifiable by outreach engagement and education.

Plasma Aß42/40 and cognitive variability are associated with cognitive function in Black Americans: Findings from the AA-FAIM cohort.

Introduction: It is critical to develop more inclusive Alzheimer's disease (AD) research protocols to ensure that historically excluded groups are included in preclinical research and have access to timely diagnosis and treatment. If validated in racialized groups, plasma AD biomarkers and measures of subtle cognitive dysfunction could provide avenues to expand diversity in preclinical AD research. We sought to evaluate the utility of two easily obtained, low-burden disease markers, plasma amyloid beta (Aß)42/40, and intra-individual cognitive variability (IICV), to predict concurrent and longitudinal cognitive performance in a sample of Black adults. Methods: Two hundred fifty-seven Black participants enrolled in the African Americans Fighting Alzheimer's in Midlife (AA-FAIM) study underwent at least one cognitive assessment visit; a subset of n = 235 had plasma samples. Baseline IICV was calculated as the standard deviation across participants' z scores on five cognitive measures: Rey Auditory Verbal Learning Test Delayed Recall, Trail Making Test Parts A and B (Trails A and B), and Boston Naming Test. Using mixed effects regression models, we compared concurrent and longitudinal models to baseline plasma Aß42/40 or IICV by age interactions. PrecivityAD assays quantified baseline plasma Aß42/40. Results: IICV was associated with concurrent/baseline performance on several outcomes but did not modify associations between age and cognitive decline. In contrast, plasma Aß42/40 was unrelated to baseline cognitive performance, but a pattern emerged in interactions with age in longitudinal models of Trails A and B and Rey Auditory Verbal Learning Test total learning trials. Although not significant after correcting for multiple comparisons, low Aß42/40 was associated with faster cognitive declines over time. Discussion: Our results are promising as they extend existing findings to an Black American sample using low-cost, low-burden methods that can be implemented outside of a research center, thus supporting efforts for inclusive AD biomarker research.

Social anhedonia and other indicators of risk for schizophrenia: Theory and inquiry.

In this commentary, the author traces theoretical contributions that fueled her interest in the role of social/interpersonal striving, relating, and enjoyment in terms of schizophrenia. Social anhedonia is discussed in the context of schizophrenia. The author reviews selective empirical evidence indicating that social anhedonia has a unique role in terms of risk for schizophrenia as well as schizophrenia outcome. Other risk indicators for adult schizophrenia-spectrum outcomes are briefly considered. The author discusses the measurement of social anhedonia across the lifespan and transdiagnostically. Finally, this commentary offers a critique of current strategies for risk calculation.

Racial Differences in Associations of Cognitive Health Status With Happiness, Helplessness, and Hopelessness Among Older Adults: An Exploratory Study.

Background: The relationship between healthy and positive aging and dementia and cognitive impairment has received limited attention in the field of aging. Affect impacts cognitive changes and processes, and cognitive impairment is associated with affective comorbidities. The purpose of the study was to examine (a) whether happiness, helplessness, and hopelessness are linked to cognitive health status, and (b) whether these associations differ by race. Methods: Participants were enrollees in the Wisconsin Alzheimer's Disease Research Center's Clinical Core (ADRC). Average age at baseline was 60.85 (SD = 8.65), 73.70 (SD = 8.02), and 73.80 (SD = 9.59) years for cognitively normal individuals, individuals with MCI, and individuals with dementia, respectively. Results: In the full sample, chi-square test results revealed associations between Cognitive Health Status (CHS) and (a) happiness, χ2(2) = 6.06, p < 0.05, (b) helplessness, χ2(2) = 6.44, p < 0.05, and (c) hopelessness, χ2(2) = 14.11, p < 0.01. Conclusion: This study provides support for the association of both positive and negative affect with cognitive health status in middle- to older-aged adults.

The Transdiagnostic Nature of Social Anhedonia: Historical and Current Perspectives.

In this chapter, we trace the historical roots of the social anhedonia (SoA) construct to current conceptualizations. We first describe the aspects of SoA that distinguish it from anhedonia in general. We summarize evidence that SoA is a transdiagnostic symptom and risk factor. Although several forms of psychopathology are associated with elevated rates of self-reported SoA, one unresolved issue is whether the processes and mechanisms underlying SoA in one disorder are the same as the processes and mechanisms underlying SoA seen in another disorder. We assert that there may be different causal factors underlying SoA across disorders. Considering both the principles of equifinality and multifinality, we offer an integrative model for social reward processing. This conceptualization considers roles for the following: attention; social cognition, including, but not limited to, social skills; reward learning and valuation; working memory; anticipation, prediction, and remembering; and motivation and effort. We conclude that SoA may be caused by multiple underlying impairments, all of which may serve as targets for intervention. This conceptualization is provided as an impetus for further research in the area.

The characterization of social anhedonia and its correlates in schizophrenia and schizoaffective patients.

Although social hedonic capacity is often assessed in clinical settings, its operational definitions have not been evaluated for concurrent validity. One hundred and twenty-five patients with schizophrenia and schizoaffective disorder were classified according to their self-reported social hedonic functioning into three groups on the basis of their total scores on the Anticipatory and Consummatory Interpersonal Pleasure Scale (ACIPS). Participants were assessed before discharge using questionnaires and psychiatric rating scales. Using an empirically based cutoff score, we identified three groups: an intact social hedonic group (WNL), a socially anhedonic group (SA), and a socially hypohedonic group (i.e., those with scores intermediate between normal functioning and aberrantly low functioning, H). The SA patients were significantly different from the two other groups (WNL and H) by their higher severity of psychopathology, lower levels of self-efficacy, and less self-esteem. The SA patients also reported less perceived social support, poorer quality of life, and less subjective recovery. Our findings indicate that social anhedonia is a meaningful target for intervention. Further implications of our findings are discussed.

The assessment of interpersonal pleasure: introduction of the Anticipatory and Consummatory Interpersonal Pleasure Scale (ACIPS) and preliminary findings.

Although several valid measures of pleasure and anhedonia exist, there is a relative paucity of measures that adequately assess pleasure for social interactions. The Anticipatory and Consummatory Interpersonal Pleasure Scale (ACIPS) is a measure specifically designed to assess hedonic capacity for social and interpersonal pleasure. Various aspects of the validity and reliability of the ACIPS were examined in several ways. First, we assessed the factor structure as well as the internal consistency, convergent, and discriminant validity of the ACIPS in 496 young adults recruited from undergraduate classes. Second, we investigated the temporal stability of the measure by having a subset of the group return for retesting. Results from the factor analysis suggested a three-factor model. The ACIPS was found to be highly reliable in terms of internal consistency and test-retest stability. Further, the ACIPS correlated in a theoretically meaningful way with other measures of pleasure and affect. The current research indicates that the ACIPS is a reliable and valid questionnaire to assess hedonic capacity for social and interpersonal pleasure in nonclinical samples. Suggestions for further clinical and research applications using the ACIPS are offered.

Hint, hint: theory of mind performance in schizotypal individuals.

Studying Theory of Mind (ToM) performance in nonclinical populations may assist our understanding of underlying cognitive processes and contributing factors. ToM was assessed in three groups of psychometrically identified schizotypes, namely, individuals elevated on scales assessing positive schizotypy, those elevated on scales assessing negative schizotypy, and those elevated on both positive and negative schizotypy scales, using two hinting tasks. Individuals characterized by positive schizotypy showed poorer ToM performance compared with controls. The results suggest that individuals with elevated positive schizotypy scores experience more difficulty inferring the meaning of others' mental states (i.e., intentions) via indirect speech, such as hints. The negative schizotypy group did not differ from the nonschizotypy group in ToM performance. These findings are considered in terms of cognitive processing styles and implications for possible intervention. They also provide support for the inclusion of multiple groups of schizotypal individuals when assessing social cognition.

Theory of Mind and psychometric schizotypy.

The extent to which Theory of Mind impairments are a trait associated with schizotypy is unclear. To date, findings have been mixed. We compared two groups of psychometrically identified schizotypes, namely, those characterized by positive schizotypy (perceptual aberrations and magical ideation; n=36) and those characterized by negative schizotypy (social anhedonia; n=30) to a low schizotypy comparison group (n=68) in terms of their Theory of Mind performance. Theory of Mind was assessed in two ways: a composite Hinting Task and the Reading the Mind in the Eyes Test. The groups were also compared in terms of their self-reported levels of referential thinking. Our results indicate that individuals characterized by positive schizotypy show Theory of Mind deficits, as measured by the Hinting Task. The three groups did not differ in terms of the Eyes Test. Referential thinking was significantly associated with the Eyes Test but not the Hinting Task. Overall these findings suggest that different aspects of schizotypy are associated differentially with Theory of Mind deficits. The results also provide further rationale for the inclusion of multiple tasks when attempting to study multifaceted constructs such as Theory of Mind.

Schizotypy and altered digit ratios: a second look.

Alterations in the ratio between the 2nd and 4th finger digits have been posited as a potential indicator of increased liability for neurodevelopmental disorders such as autism and schizophrenia. We compared digit ratios in two groups of psychometrically-identified schizotypes, namely, those characterized by positive schizotypy (perceptual aberrations and magical ideation; n=76) and those characterized by negative schizotypy (social anhedonia; n=64), to a control group (n=110). The groups were also compared in terms of their performance on a measure of Theory of Mind, namely, the Reading the Mind in the Eyes Test (RMET) and trait affect, as measured by the PANAS. Our results indicate that neither negative schizotypy nor positive schizotypy is associated with altered digit ratios. Similarly, the groups showed no significant differences on the RMET. However, we observed a small but significant inverse association between Theory of Mind performance and negative affect. The findings are considered in light of the extant literature. These results call into question the viability of altered digit ratios to serve as an indicator of increased risk for schizophrenia-spectrum disorders.

Attentional deficits in cocaine-dependent patients: converging behavioral and electrophysiological evidence.

Although there are several reports of patients with cocaine dependence displaying cognitive deficits, the nature of their information processing deficits is not well characterized. In the present study, the attentional performance of cocaine-dependent patients (n=14) was examined and compared with that of healthy control individuals (n=15). Attention was assessed using an auditory oddball event-related task as well as the Continuous Performance Test (CPT, Identical Pairs version). The cocaine-dependent group displayed P300 amplitude reduction compared to controls. The group difference in P300 response latency did not reach significance. On the CPT, the cocaine-dependent patients displayed significantly poorer discriminability and greater errors of commission than the controls. There was a positive correlation between performance on the oddball event-related task and performance on the CPT. This investigation provides converging behavioral and electrophysiological evidence of attentional deficits in cocaine-dependent patients.