ABSTRACT
Letters from Silas Burroughs to his junior partner Henry Wellcome and other business associates have recently come to light Written during his travels (1880-1882) soon after the establishment of their pharmaceutical company, the letters show how this energetic, resourceful and imaginative salesman developed and expanded the business overseas and tackled the problems of preservation, packaging and marketing of medicines in tropical countries.
Subject(s)
Correspondence as Topic/history , Drug Industry/history , History, 19th Century , United StatesSubject(s)
Trypanosomiasis/therapy , Animals , Humans , Insect Vectors , Trypanosomiasis/diagnosis , Trypanosomiasis/parasitologySubject(s)
Parasitology/history , Tropical Medicine/history , History, Modern 1601- , United KingdomSubject(s)
Filariasis/drug therapy , Ivermectin/analogs & derivatives , Animals , Anti-Inflammatory Agents/therapeutic use , Arsenicals/therapeutic use , Benzimidazoles/therapeutic use , Diethylcarbamazine/therapeutic use , Drug Evaluation, Preclinical , Filaricides/therapeutic use , Filarioidea/drug effects , Filarioidea/metabolism , Humans , Lactones/therapeutic use , Onchocerciasis/drug therapy , Suramin/therapeutic useABSTRACT
A new technique for determining the trypanocidal activity of body fluids has been devised, using very small quantities in the wells of plastic microtest plates. The activities of blood and tissue fluid of rabbits have been measured after the infection of melarsoprol, suramin, diminazene aceturate and isometamidium chloride. Activity against Trypanosoma (Trypanozoon) brucei persisted in body fluids for a shorter time in treated normal rabbits than in treated rabbits infected with the trypanosome. The difference was caused by the participation of the immune response of the infected animals. The new technique was sensitive enough to detect these interactions of chemotherapy and immunology and should be of use in the study of new trypanocidal compounds.