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1.
Adv Mater ; 32(28): e2002495, 2020 Jul.
Article in English | MEDLINE | ID: mdl-32462669

ABSTRACT

By virtue of their narrow emission bands, near-unity quantum yield, and low fabrication cost, metal halide perovskites hold great promise in numerous aspects of optoelectronic applications, including solid-state lighting, lasing, and displays. Despite such promise, the poor temperature tolerance and suboptimal quantum yield of the existing metal halide perovskites in their solid state have severely limited their practical applications. Here, a straightforward heterogeneous interfacial method to develop superior thermotolerant and highly emissive solid-state metal halide perovskites is reported and their use as long-lasting high-temperature and high-input-power durable solid-state light-emitting diodes is illustrated. It is found that the resultant materials can well maintain their superior quantum efficiency after heating at a temperature over 150 °C for up to 22 h. A white light-emitting diode (w-LED) constructed from the metal halide perovskite solid exhibits superior temperature sustainable lifetime over 1100 h. The w-LED also displays a highly durable high-power-driving capability, and its working current can go up to 300 mA. It is believed that such highly thermotolerant metal halide perovskites will unleash the possibility of a wide variety of high-power and high-temperature solid-state lighting, lasing, and display devices that have been limited by existing methods.

2.
Ind Psychiatry J ; 28(2): 176-184, 2019.
Article in English | MEDLINE | ID: mdl-33223709

ABSTRACT

BACKGROUND: Caregivers are playing a vital role in mentally ill patients in India. Families of children with intellectual disability encounter a high degree of stress such as physical, emotional, and financial. AIM: The aim of this study was to compare and evaluate the caregiver burden and depression between the special school-going children and nonschool-going children with intellectual disability. MATERIALS AND METHODS: The present study was conducted on caregivers of patients with intellectual disability at Radianz Health Care and Research Private Limited, Ahana Hospitals, Akash Special School, and M. S. Chellamuthu Trust and Research Foundation, Madurai. The Zarit Burden Interview scale was utilized to assess the level of burden experienced by the caregivers. The Major Depression Inventory scale was utilized to assess the severity of depression experienced by the caregivers. The Binet Kamat Test of Intelligence was administered by a psychologist to assess the IQ level of the children. RESULTS: Totally 80 caregivers were participated in the study. The mothers of children with intellectual disability suffered from burden and depression when compared to the fathers (P < 0.0001). The parents of nonschool-going children had a higher level of burden and depression as compared to the parents of special school-going children (P < 0.0001). CONCLUSION: Special school is playing a vital role for children with intellectual disability. It can be reasonably concluded from the study that both the groups face burden and depression. However, the severity of burden and depression is comparatively higher among parents of nonschool-going children.

3.
Spectrochim Acta A Mol Biomol Spectrosc ; 181: 137-147, 2017 Jun 15.
Article in English | MEDLINE | ID: mdl-28351820

ABSTRACT

Blue-shifted hydrogen-bonded complexes of fluoroform (CHF3) with benzene (C6H6) and acetylene (C2H2) have been investigated using matrix isolation infrared spectroscopy and ab initio computations. For CHF3-C6H6 complex, calculations performed at the B3LYP and MP2 levels of theory using 6-311++G (d,p) and aug-cc-pVDZ basis sets discerned two minima corresponding to a 1:1 hydrogen-bonded complex. The global minimum correlated to a structure, where the interaction is between the hydrogen of CHF3 and the π-electrons of C6H6 and a weak local minimum was stabilized through H…F interaction. For the CHF3-C2H2 complex, computation performed at MP2/aug-cc-pVDZ level of theory yielded two minima, corresponding to the cyclic C-H…π complex A (global) and a linear C-H…F (n-σ) complex B (local). Experimentally a blue-shift of 32.3cm-1 and 7.7cm-1 was observed in the ν1 C-H stretching mode of CHF3 sub-molecule in Ar matrix for the 1:1 C-H…π complexes of CHF3 with C6H6 and C2H2 respectively. Natural bond orbital (NBO), Atoms-in-molecule (AIM) and energy decomposition (EDA) analyses were carried out to explain the blue-shifting and the nature of the interaction in these complexes.

4.
J Phys Chem A ; 121(10): 2121-2131, 2017 Mar 16.
Article in English | MEDLINE | ID: mdl-28235181

ABSTRACT

Trimethyl phosphite (TMPhite) was photooxidized to trimethyl phosphate (TMP) in N2, O2, and para-H2 matrixes at low temperatures to correlate the conformational landscape of these two molecules. The photooxidation produced the trans (TGG)-rich conformer with respect to the ground state gauche (GGG) conformer of TMP in N2 and O2 matrixes, which has diverged from the conformational composition of freshly deposited pure TMP in the low-temperature matrixes. The enrichment of the trans conformer in preference to the gauche conformer of TMP during photooxidation is due to the TMPhite precursor, which exists exclusively in the trans conformer. Interestingly, whereas the photooxidized TMP molecule suffers site effects possibly due to the local asymmetry in N2 and O2 matrixes, in the para-H2 matrix owing to the quantum crystal nature the site effects were observed to be self-repaired.

5.
J Phys Chem A ; 118(29): 5529-39, 2014 Jul 24.
Article in English | MEDLINE | ID: mdl-24979667

ABSTRACT

The 1:1 hydrogen-bonded complex of fluoroform and hydrogen chloride was studied using matrix-isolation infrared spectroscopy and ab initio computations. Using B3LYP and MP2 levels of theory with 6-311++G(d,p) and aug-cc-pVDZ basis sets, the structures of the complexes and their energies were computed. For the 1:1 CHF3-HCl complexes, ab initio computations showed two minima, one cyclic and the other acyclic. The cyclic complex was found to have C-H · · · Cl and C-F · · · H interactions, where CHF3 and HCl sub-molecules act as proton donor and proton acceptor, respectively. The second minimum corresponded to an acyclic complex stabilized only by the C-F · · · H interaction, in which CHF3 is the proton acceptor. Experimentally, we could trap the 1:1 CHF3-HCl cyclic complex in an argon matrix, where a blue-shift in the C-H stretching mode of the CHF3 sub-molecule was observed. To understand the nature of the interactions, Atoms in Molecules and Natural Bond Orbital analyses were carried out to unravel the reasons for blue-shifting of the C-H stretching frequency in these complexes.


Subject(s)
Chlorofluorocarbons, Methane/chemistry , Hydrochloric Acid/chemistry , Quantum Theory , Hydrogen Bonding , Spectrophotometry, Infrared
6.
J Mater Sci Mater Med ; 19(9): 3005-14, 2008 Sep.
Article in English | MEDLINE | ID: mdl-18389347

ABSTRACT

A ketene based Low molecular weight polymer (LMKP) having ester functional group was prepared using glycine through surface initiated anionic polymerization. NMR, ATR-FTIR & SEC were used to characterize the LMKP. The LMKP and acrylamide (AAm) were co-polymerised in methyl ethyl ketone to yield semi-IPN nanohydrogels (NHG). Benzoyl peroxide (BPO) was used as an initiator and N,N-methylene bisacrylamide (MBA) as crosslinking agent. Formation of NHG was confirmed through frequency shift in LMKP and poly acrylamide (PAAm) in FTIR spectroscopy. Photon correlation spectroscopy reveals that the sizes of the NHG were in the range of 140-225 nm and Transmission Electron Micrograph (TEM) also confirms the nano dimension of NHG. Biocompatibility of the NHG was confirmed through the cytotoxicity analysis. The swelling and diffusion behaviour of NHG, prepared under various formulations, were evaluated. The swelling pattern of NHG was studied at different pH conditions. The drug delivery capacity of NHG was investigated using ciprofloxacin as a model drug. The drug release kinetics of NHG suggested their anomalous (non-fickian) behaviour.


Subject(s)
Acrylic Resins/chemistry , Ethylenes/chemistry , Hydrogels/chemistry , Ketones/chemistry , Nanotechnology/methods , Polyesters/chemistry , Biocompatible Materials , Chemistry, Pharmaceutical/methods , Ciprofloxacin/pharmacokinetics , Drug Delivery Systems , Ions , Nanoparticles/chemistry , Photons , Polymers/chemistry , Spectroscopy, Fourier Transform Infrared , Surface Properties
7.
Colloids Surf B Biointerfaces ; 62(2): 312-8, 2008 Apr 01.
Article in English | MEDLINE | ID: mdl-18068339

ABSTRACT

The variations in antioxidant potentials and indole alkaloid content were studied in the present investigation, in two varieties (rosea and alba) of Catharanthus roseus, an important herb used in traditional as well as modern medicine, exposed to water deficit stress. The antioxidant and alkaloid profiles were estimated from root, stem, leaf, flowers and pods. The antioxidant potentials were examined in terms of non-enzymatic antioxidant molecules and activities of antioxidant enzymes. The non-enzymatic antioxidant molecules studied were ascorbic acid (AA), alpha-tocopherol (alpha-toc) and reduced glutathione (GSH). The estimated antioxidant enzymes were superoxide dismutase (SOD), ascorbate peroxidase (APX), catalase (CAT), peroxidase (POX) and polyphenol oxidase (PPO). The antioxidant concentrations and activities of antioxidant enzymes were high under water deficit stress in all parts of the plants. Indole alkaloid content was high in the roots of rosea variety in response to stress when compared to alba variety.


Subject(s)
Alkaloids/metabolism , Antioxidants/metabolism , Catharanthus/metabolism , Disasters , Indoles/metabolism , Water/physiology , Ascorbate Peroxidases , Ascorbic Acid/metabolism , Catalase/metabolism , Catechol Oxidase/metabolism , Catharanthus/drug effects , Catharanthus/enzymology , Glutathione/metabolism , Peroxidases/metabolism , Superoxide Dismutase/metabolism , Vitamin E/metabolism
8.
Colloids Surf B Biointerfaces ; 60(1): 7-11, 2007 Oct 15.
Article in English | MEDLINE | ID: mdl-17681765

ABSTRACT

The effect of plant growth promoting rhizobacteria (PGPR) like Pseudomonas fluorescens on growth parameters and the production of ajmalicine were investigated in Catharanthus roseus under drought stress. The plants under pot culture were subjected to 10, 15 and 20 days interval drought (DID) stress and drought stress with Pseudomonas fluorescens at 1mgl(-1) and 1mgl(-1)Pseudomonas fluorescens alone from 30 days after planting (DAP) and regular irrigation was kept as control. The plants were uprooted on 41 DAS (10 DID), 46 DAS (15 DID) and 51 DAS (20 DID). Drought stress decreased the growth parameters and increased the ajmalicine content. But the treatment with Pseudomonas fluorescens enhanced the growth parameters under drought stress and partially ameliorated the drought induced growth inhibition by increasing the fresh and dry weights significantly. The ajmalicine content was again increased due to Pseudomonas fluorescens treatment to the drought stressed plants. From the results of this investigation, it can be concluded that, the seedling treatments of native PGPRs can be used as a good tool in the enhancement of biomass yield and alkaloid contents in medicinal plants, as it provides an eco-friendly approach and can be used as an agent in water deficit stress amelioration.


Subject(s)
Biomass , Catharanthus/metabolism , Catharanthus/microbiology , Dehydration/metabolism , Pseudomonas fluorescens/physiology , Secologanin Tryptamine Alkaloids/metabolism , Water/metabolism , Catharanthus/anatomy & histology , Catharanthus/growth & development
9.
Colloids Surf B Biointerfaces ; 60(1): 110-6, 2007 Oct 15.
Article in English | MEDLINE | ID: mdl-17643271

ABSTRACT

The present investigation was conducted to determine whether CaCl(2) increases Catharanthus roseus drought tolerance and if such tolerance is correlated with changes in oxidative stress, osmoregulation and indole alkaloid accumulation. C. roseus plants were grown under water deficit environments with or without CaCl(2). Drought induced oxidative stress was measured in terms of lipid peroxidation (LPO) and H(2)O(2) contents, osmolyte concentration, proline (PRO) metabolizing enzymes and indole alkaloid accumulation. The plants under pot culture were subjected to 10, 15 and 20 days interval drought (DID) stress and drought stress with 5mM CaCl(2) and 5mM CaCl(2) alone from 30 days after planting (DAP) and regular irrigation was kept as control. The plants were uprooted on 41 DAS (10 DID), 46 DAS (15 DID) and 51 DAS (20 DID). Drought stressed plants showed increased LPO, H(2)O(2), glycine betaine (GB) and PRO contents and decreased proline oxidase (PROX) activity and increased gamma-glutamyl kinase (gamma-GK) activity when compared to control. Addition of CaCl(2) to drought stressed plants lowered the PRO concentration by increasing the level of PROX and decreasing the gamma-GK activities. Calcium ions increased the GB contents. CaCl(2) appears to confer greater osmoprotection by the additive role with drought in GB accumulation. The drought with CaCl(2)-treated C. roseus plants showed an increase in total indole alkaloid content in shoots and roots when compared to drought stressed and well-watered plants.


Subject(s)
Calcium Chloride/pharmacology , Catharanthus/drug effects , Dehydration/drug therapy , Indole Alkaloids/metabolism , Oxidative Stress/drug effects , Proline/metabolism , Catharanthus/metabolism , Hydrogen Peroxide/metabolism
10.
Colloids Surf B Biointerfaces ; 60(2): 195-200, 2007 Nov 15.
Article in English | MEDLINE | ID: mdl-17643272

ABSTRACT

Changes in antioxidant potentials and indole alkaloid, ajmalicine, production were studied in Catharanthus roseus (L.) G. Don. plants under treatment with gibberellic acid (GA(3)). The GA(3) treatments were given in two ways, foliar spray and soil drenching methods on 30, 45, 60 and 75 days after planting (DAP). The plants were uprooted randomly on 90 DAP and separated into root, stem and leaves and used for analyses. The antioxidant potential was studied in terms of non-enzymatc antioxidant molecules like ascorbic acid (AA), alpha-tocopherol (alpha-toc) and reduced glutathione (GSH) and activities of antioxidant enzyme, viz., superoxide dismutase (SOD), ascorbate peroxidase (APX) and catalase (CAT). The alkaloid ajmalicine was extracted and estimated from roots of both control and treated plants. It was found that, GA(3) has a profound effect upon the antioxidant potentials and it caused a significant enhancement in the production of ajmalicine when compared to untreated control as well as foliar-sprayed plants. There was no significant enhancement in GSH and ajmalicine content under GA(3) foliar spray in C. roseus. These preliminary results suggest that, the application of GA(3) may be a useful tool to increase the antioxidant potential and alkaloid production in medicinal plants like C. roseus.


Subject(s)
Antioxidants/metabolism , Catharanthus/drug effects , Catharanthus/metabolism , Gibberellins/pharmacology , Secologanin Tryptamine Alkaloids/metabolism , Antioxidants/chemistry , Ascorbate Peroxidases , Catalase/chemistry , Catalase/drug effects , Catalase/metabolism , Catharanthus/chemistry , Enzyme Activation/drug effects , Glutathione/chemistry , Glutathione/metabolism , Peroxidases/chemistry , Peroxidases/drug effects , Peroxidases/metabolism , Secologanin Tryptamine Alkaloids/chemistry , Superoxide Dismutase/chemistry , Superoxide Dismutase/drug effects , Superoxide Dismutase/metabolism , alpha-Tocopherol/chemistry , alpha-Tocopherol/metabolism
11.
Colloids Surf B Biointerfaces ; 60(2): 201-6, 2007 Nov 15.
Article in English | MEDLINE | ID: mdl-17643970

ABSTRACT

A pot culture experiment was conducted to estimate the drought stress mitigating effect of ketoconazole (KCZ), a fungicide cum plant growth regulator, in Catharanthus roseus plants. The plants under pot culture were subjected to drought stress and drought stress with KCZ from 30 days after sowing (DAS) and regular irrigation was kept as control. Antioxidant contents and activities of antioxidant enzymes were estimated from root, stem and leaf of both control and treated plants. The alkaloid ajmalicine was extracted and estimated from the roots of control, drought stressed and KCZ treated plants. Individual and combined drought stress and KCZ treatments increased ascorbic acid, alpha-tocopherol contents, superoxide dismutase, ascorbate peroxidase, catalase and polyphenol oxidase activities when compared to control. There was a significant enhancement in ajmalicine production under KCZ treated plants under drought stress when compared to well watered control as well as drought stressed plants. The KCZ treatment resulted in partial mitigation of drought stress by increasing the antioxidant potentials in C. roseus plants.


Subject(s)
Antioxidants/metabolism , Catharanthus/drug effects , Catharanthus/metabolism , Dehydration/metabolism , Ketoconazole/pharmacology , Antioxidants/chemistry , Ascorbate Peroxidases , Ascorbic Acid/chemistry , Ascorbic Acid/metabolism , Catalase/chemistry , Catalase/drug effects , Catalase/metabolism , Catharanthus/chemistry , Dehydration/prevention & control , Enzyme Activation/drug effects , Peroxidases/chemistry , Peroxidases/drug effects , Peroxidases/metabolism , Secologanin Tryptamine Alkaloids/chemistry , Secologanin Tryptamine Alkaloids/metabolism , Superoxide Dismutase/chemistry , Superoxide Dismutase/drug effects , Superoxide Dismutase/metabolism , alpha-Tocopherol/chemistry , alpha-Tocopherol/metabolism
12.
Colloids Surf B Biointerfaces ; 60(2): 180-6, 2007 Nov 15.
Article in English | MEDLINE | ID: mdl-17644352

ABSTRACT

The application of triazole fungicides is a common practice in the cultivation of carrot (Daucus carota L.) plants. It is there for seems important to test the changes that are occurring in this food crop under triazoles, the non-traditional plant growth regulators, treatments in order to identify the extent to which it tolerate the fungicide application and thereby make it an economical food crop. A field experiment was conducted to find out the effects of two triazole fungicides (hexaconazole (HEX) and paclobutrazol (PBZ) at 20mg l(-1) plant(-1)) on the biomass, yield, electrolyte leakage, lipid peroxidation and antioxidant potential of carrot. The treatments were given to plants on 15, 30 and 45 days after sowing (DAS). The plants were uprooted for analyses of growth and biochemical parameters on 60 DAS. It was found that both HEX and PBZ have significant effects on the growth and biochemical parameters of this plant. Among the triazoles used, PBZ performed best in terms of anthocyanin, protein, amino acid, proline, starch and sugar, contents whereas HEX enhanced carotenoids, fresh weight, dry weight and biomass. There was no significant variation in chlorophyll ('a' and 'b') contents between the two triazole treated plants, but HEX and PBZ proved best when compared to untreated control plants. HEX and PBZ increased alpha- and beta-amylases enzymes activities to a significant level. Out of these two triazoles, PBZ performed best in increasing the starch hydrolyzing enzymes activities. The non-enzymatic antioxidant, reduced glutathione (GSH) and antioxidant enzyme ascorbate peroxidase (APX) were increased under fungicide applications. The data suggests that, the application of triazole fungicides may be a useful tool to increase the tuber quality as well as quantity in carrot plants, apart from their fungicidal properties.


Subject(s)
Antioxidants/metabolism , Daucus carota/drug effects , Electrolytes/metabolism , Lipid Peroxidation/drug effects , Triazoles/pharmacology , Agriculture , Amino Acids/chemistry , Amino Acids/metabolism , Antioxidants/chemistry , Ascorbate Peroxidases , Biomass , Carbohydrates/chemistry , Daucus carota/chemistry , Daucus carota/physiology , Electrolytes/chemistry , Enzyme Activation/drug effects , Fungicides, Industrial/pharmacology , Glutathione/chemistry , Glutathione/metabolism , Peroxidases/chemistry , Peroxidases/drug effects , Peroxidases/metabolism , Proline/chemistry , Proline/metabolism , Starch/chemistry , Starch/metabolism
13.
J Zhejiang Univ Sci B ; 8(7): 453-7, 2007 Jul.
Article in English | MEDLINE | ID: mdl-17610323

ABSTRACT

An experiment was conducted on Catharanthus roseus to study the effect of seed treatments with native diazotrophs on its seedling growth and antioxidant enzyme activities. The treatments had significant influence on various seedling parameters. There is no significant influence on dry matter production with the diazotrophs, Azospirillum and Azotobacter. However, the vital seedling parameters such as germination percentage and vigour index were improved. Azotobacter treatment influenced maximum of 50% germination, whereas Azospirillum and Azotobacter were on par with C. roseus with respect to their vigour index. There was significant difference in the population of total diazotrophs. Azospirillum and Azotobacter between rhizosphere and non-rhizosphere soils of C. roseus had the same trend and were observed at various locations of the study. The activities of antioxidant enzymes such as superoxide dismutase (SOD), peroxidase (POX) and catalase (CAT) were increased to a significant extent due to the treatment with diazotrophs.


Subject(s)
Antioxidants/metabolism , Catharanthus/growth & development , Catharanthus/metabolism , Azospirillum/physiology , Azotobacter/physiology , Catalase/metabolism , Catharanthus/microbiology , Germination , Peroxidase/metabolism , Seedlings/growth & development , Seeds/microbiology , Superoxide Dismutase/metabolism , Symbiosis
14.
Colloids Surf B Biointerfaces ; 59(2): 150-7, 2007 Oct 01.
Article in English | MEDLINE | ID: mdl-17560094

ABSTRACT

Catharanthus roseus (L.) G. Don plants were grown in different water regimes in order to study the drought induced osmotic stress and proline (PRO) metabolism, antioxidative enzyme activities and indole alkaloid accumulation. The plants under pot culture were subjected to 10, 15 and 20 days interval drought (DID) stress from 30 days after sowing (DAS) and regular irrigation was kept as control. The plants were uprooted on 41DAS (10DID), 46DAS (15DID) and 51DAS (20DID). The drought stressed plants showed increased aminoacid (AA), glycine betaine (GB) and PRO contents and decreased proline oxidase (PROX) and increased gamma-glutamyl kinase (gamma-GK) activities when compared to control. The antioxidative enzymes like peroxidase (POX) and polyphenol oxidase (PPO) increased to a significant level in drought stressed plants when compared to control. The drought stressed C. roseus plants showed an increase in total indole alkaloid content in shoots and roots when compared to well-watered control plants. Our results suggest that the cultivation of medicinal plants like C. roseus in water deficit areas would increase its PRO metabolism, osmoregulation, defense system and the level of active principles.


Subject(s)
Antioxidants/metabolism , Catharanthus/enzymology , Indole Alkaloids/metabolism , Water-Electrolyte Balance/physiology , Catharanthus/metabolism , Dehydration/metabolism , Osmosis/physiology , Water/metabolism
16.
Magn Reson Med ; 41(3): 550-4, 1999 Mar.
Article in English | MEDLINE | ID: mdl-10204879

ABSTRACT

A mathematical model is presented to study the generation of the early response phenomenon in fMRI. Initially, we demonstrate that a simple combination of the changes taking place in cerebral blood volume and flow could create the transient early signal decrease, by analyzing their effects on total per voxel deoxyhemoglobin content. Also, we examine the traditional paradigm for the early response: that it may be caused by an early burst of oxidative metabolism and conclude that such changes also explain the early transient response. We suggest that the volume effect may play a role in the generation of the early response phenomenon along with an early upregulation of oxidative metabolism, and that this role may be important if the early response phenomenon is shown to occur at the level of the venous blood pool, and not just at the level of the capillary bed.


Subject(s)
Cerebrovascular Circulation , Magnetic Resonance Imaging/methods , Models, Cardiovascular , Hemoglobins/analysis , Humans , Models, Neurological , Oxygen Consumption/physiology , Phantoms, Imaging , Sensitivity and Specificity , Up-Regulation
17.
Magn Reson Imaging ; 17(1): 9-20, 1999 Jan.
Article in English | MEDLINE | ID: mdl-9888394

ABSTRACT

A mathematical model that characterizes the response of venous oxygenation to changes in cerebral blood flow (rCBF) and oxygen consumption has been previously presented. We use this model to examine the dampening phenomenon in functional MRI (fMRI) signals with rapidly alternating periodic stimulation bursts. Using a mass balance approach, the equations for an input-output model are derived and solved using Matlab (the Math Works Inc.). Changes in venous oxygenation are related to the results of fMRI experiments using progressively shorter periods of stimulation. An impulse-response function for the model is derived in an attempt to explore the source of the lag in cerebral hemodynamics. Increasing the frequency of stimulation bursts eventually produces a dampening in the fMRI signal. The dampening phenomenon in fMRI signals occurs with stimulation of high frequency on-off alternation. The dynamics of signal dampening, as well as the impulse-response function of a blood oxygen level-dependent model, lend strong indirect support to the hypothesis that blood oxygen level-dependent contrast at the level of the venous blood pool, rather than R1 inflow effects or changes in oxygenation at the level of the capillary bed, underlies the observed signal changes in fMRI.


Subject(s)
Cerebrovascular Circulation , Magnetic Resonance Imaging , Oxygen/blood , Blood Flow Velocity , Humans , Models, Theoretical , Photic Stimulation
18.
Invest Radiol ; 30(11): 669-82, 1995 Nov.
Article in English | MEDLINE | ID: mdl-8557508

ABSTRACT

RATIONALE AND OBJECTIVES: Variations in venous deoxyhemoglobin levels in response to neuronal activation represent a complex interplay between focal changes in cerebral blood flow (CBF), cerebral blood volume (CBV), and regional metabolism. The authors present a mathematic model that characterizes the response of venous oxygenation to changes in these variables. METHODS: Using a mass balance approach, the equations for a simple input-output model are derived and solved using Matlab. Changes in blood oxygenation are related to available results from functional magnetic resonance imaging experiments. RESULTS: Increases in CBF produce declines in oxygen extraction fraction and venous deoxyhemoglobin according to Fick's law, and are quantitatively in agreement with available magnetic resonance and positron-emission tomography data. A flow-volume envelope defines the changes in CBF relative to CBV. CONCLUSIONS: It is possible to obtain a quantitative understanding of changes in blood oxygenation and to relate these changes to the observed dynamics of magnetic resonance signal change in the setting of functional stimulation.


Subject(s)
Brain/metabolism , Magnetic Resonance Imaging , Models, Biological , Oxygen/blood , Algorithms , Blood Volume , Brain/diagnostic imaging , Brain/physiology , Capillaries/metabolism , Cerebral Veins , Cerebrovascular Circulation , Computer Simulation , Hemoglobins/metabolism , Humans , Magnetic Resonance Imaging/methods , Magnetic Resonance Spectroscopy , Microcirculation , Neurons/metabolism , Neurons/physiology , Oxygen Consumption , Oxyhemoglobins/metabolism , Tomography, Emission-Computed , Visual Cortex/metabolism
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