ABSTRACT
The aim of the study was to compare the effectiveness of radioimmunoscintigraphy and single photon emission tomography in the diagnosis of malignant melanoma. Radioimmunoscintigraphy was carried out on 47 patients with stage I to IV malignant melanoma. Seven patients had primary melanoma; the remaining patients had 57 clinically suspected lesions. 99Tcm-F(ab)2 was injected intravenously or subcutaneously. Imaging was site and size dependent with the highest sensitivity in the lymph nodes (96%). Sensitivity was lowest in cutaneous and subcutaneous lesions using planar scintigraphy (20.5%) although it was higher using single photon emission tomography (42.8%). It is concluded that the advantages of radioimmunoscintigraphy over other methods of investigation are its specificity and selectivity. It therefore has potential as a diagnostic tool concerning the status of melanoma patients.
Subject(s)
Melanoma/diagnostic imaging , Radioimmunodetection , Tomography, Emission-Computed, Single-Photon , Adult , Aged , Female , Humans , Male , Melanoma/secondary , Middle Aged , Sensitivity and SpecificityABSTRACT
The authors describe five patients from two families with idiopathic hypertrophic subaortic stenosis, among them a brother and sister -- twins. Based on literature data and their experience, they stress the importance of the clinical and electromechanocardiographic criteria in the diagnosis of the family form of that disease, prior to the direct cardiac examination. The possible mechanisms in the genesis of predominantly local septum hypertrophia and left ventricle are discussed, an explanation being sought in the genetically conditioned changes of mitochondria and plentiful utilization of adenosine triphosphate by the defective myofibrils. Autosome mode of handing down with an incomplete penetration of the dominant gen is admitted. The differentitation of the family form of idiopathic hypertrophic subaortic stenosis is backed up as a separate nozological entiety bearing in mind another possible etiopathogenetic mechanism.
