ABSTRACT
A twenty-one-year-old woman who had been involved in an accident sustained severe trauma to the left side of her face and scalp. Because of deterioration in her neurologic condition, a number of exploratory burr holes were drilled in her skull. Fifteen years later, a 6 mm black tender nodule was noted on the left temple, close to one of the burr holes. Nodular melanoma was suspected, but results of microscopic examination proved the lesion to be a granuloma with transepidermal elimination of exogenous filamentous material. The relationship between foreign bodies and cutaneous neoplasia, genuine or simulated, is noted briefly.
Subject(s)
Foreign-Body Reaction/pathology , Melanoma/diagnosis , Skin Neoplasms/diagnosis , Skin/pathology , Sutures , Adult , Diagnosis, Differential , Facial Neoplasms/diagnosis , Female , Foreign-Body Reaction/diagnosis , HumansABSTRACT
A case of invasive papillary serous adenocarcinoma of the endocervix in pregnancy is described. The pure papillary pattern appears rarely, and to the best of our knowledge has never been described previously in pregnancy.
Subject(s)
Cystadenocarcinoma/diagnosis , Pregnancy Complications, Neoplastic , Uterine Cervical Neoplasms/diagnosis , Adult , Female , Humans , Pregnancy , Tomography, X-Ray ComputedABSTRACT
A case of parasitic leiomyoma is presented. The clinical significance of such a rare condition is discussed.
Subject(s)
Leiomyoma/diagnosis , Uterine Neoplasms/diagnosis , Adult , Diagnosis, Differential , Female , Humans , Leiomyoma/surgery , Uterine Neoplasms/surgeryABSTRACT
Complete intrapartum detachment of umbilical cord at an area of maceration is described. A severely asphyxiated infant was delivered. Antenatal maceration of umbilical cord has not yet been described. The etiology of the maceration remains obscure.
Subject(s)
Fetal Hypoxia/etiology , Umbilical Cord/pathology , Adult , Female , Humans , Pregnancy , Rupture, Spontaneous/complicationsABSTRACT
A previously healthy 70-year-old woman was hospitalized for acute pain and edema of her right leg. Deep vein thrombosis was suspected, and she was put on anticoagulant therapy. Ten hours later, she developed a massive swelling of the leg with a well-demarcated violaceous discoloration of the skin and hemorrhagic bullae. She was in deep shock with signs of disseminated intravascular coagulation and adult respiratory distress syndrome. Gram stain of an aspirate from the bullae revealed short chains of Gram-positive cocci, and multiple blood cultures showed abundant growth of Streptococcus pyogenes. Despite intensive treatment, the patient died within hours. Autopsy findings showed extensive pyomyonecrosis of the leg muscles and changes secondary to septicemia. The misleading initial clinical picture and the rarity of this disease entity in temperate climates delayed the correct diagnosis and resulted in a fatal outcome.
Subject(s)
Myositis/pathology , Streptococcal Infections/pathology , Acute Disease , Aged , Edema/diagnosis , Edema/microbiology , Edema/pathology , Female , Humans , Leg , Myositis/diagnosis , Myositis/microbiology , Sepsis/diagnosis , Sepsis/microbiology , Sepsis/pathology , Shock, Septic/diagnosis , Shock, Septic/microbiology , Shock, Septic/pathology , Streptococcal Infections/diagnosis , Streptococcal Infections/microbiology , Streptococcus pyogenes/isolation & purificationABSTRACT
Using a battery of monoclonal antibodies, we investigated the cytokeratin pattern in the epidermides of 12 human ovarian mature cystic teratomas (MCTs) and compared them with those of infant, adult, and fetal skin. Histologically, two types of epidermal layers were identified in the MCTs, a mature layer and an immature layer. The mature layer was similar to the epidermis of infants and adults, while the immature layer resembled stratified nonkeratinizing and metaplastic squamous epithelium. The cytokeratin pattern of the histologically mature epidermis in MCT was either similar to that in infants and adults or was of the fetal type. The cytokeratin expression of the histologically immature epidermis in MCT also showed many similarities to the fetal cytokeratin pattern. We conclude that histologic maturity of the epidermis in MCT is not necessarily expressed by the cytokeratin pattern, which reflects the state of molecular rather than histologic differentiation. Since prognosis in germ cell tumors is usually related to the degree of tissue maturation, our observations raise the possibility that the cytokeratin profile may eventually prove to be a valuable prognostic tool in some of the neoplasms that contain epithelial elements.
