ABSTRACT
The degrees of invasiveness, proliferative activity, morphofunctional activity of nuclei in the thyroidal gland tumors were studied, while analyzing material, obtained in 1343 patients, suffering thyroidal gland cancer (THGC) and operated on in 2000-2013 yrs. Morphological point quantity of malignancy (as a criterion of the tumor progression grade) and mitotic activity in cellular population were determined in various kinds of THGC. Undifferentiated (anaplastic carcinoma) type of THGC is the most malignant one. There were determined a spindle-like, giant-cell and squamous-cell forms of undifferentiated THGC. The presence of sites of differentiated cancer in 33% of histological preparations witnesses the interrelationship with the earlier existed pathological process.
Subject(s)
Carcinoma/epidemiology , Thyroid Gland/pathology , Thyroid Neoplasms/epidemiology , Carcinoma/pathology , Carcinoma/surgery , Carcinoma, Neuroendocrine , Carcinoma, Papillary , Female , Humans , Incidence , Lymphatic Metastasis , Male , Middle Aged , Necrosis , Neoplasm Invasiveness , Thyroid Cancer, Papillary , Thyroid Carcinoma, Anaplastic , Thyroid Gland/surgery , Thyroid Neoplasms/pathology , Thyroid Neoplasms/surgery , Thyroidectomy , UkraineABSTRACT
The elaborated method of colorectal anastomosis formation was applied for the intestinal continuity restoration after its resection for obturative colonic tumoral ileus. Insufficiency of anastomotic sutures was not revealed. Postoperative complications had occurred in 2 (6.9%) of patients. All the patients have survived.
Subject(s)
Colonic Neoplasms/complications , Colonic Neoplasms/surgery , Intestinal Obstruction/etiology , Intestinal Obstruction/surgery , Jejunoileal Bypass/methods , Female , Humans , Male , Middle AgedABSTRACT
An experience of the clinic with the surgical treatment of diffuse toxic goiter associated with autoimmune thyroiditis for the recent 16 years has been generalized based upon 258 observations. Long-term results followed in 73.6% of the patients show that an improved method of operation thought to be less radical gives good results. An immune depressive effect of the operation was noted. The investigation facilitates positive solution of the problem of the expediency of the surgical treatment of the complicated form of toxic goiter having indications for surgery.
Subject(s)
Graves Disease/surgery , Thyroidectomy , Thyroiditis, Autoimmune/complications , Adolescent , Adult , Aged , Female , Graves Disease/complications , Humans , Male , Middle AgedSubject(s)
Graves Disease/diagnosis , Palpation/methods , Thyroiditis, Autoimmune/diagnosis , Adolescent , Adult , Aged , Female , Humans , Male , Middle AgedABSTRACT
A study of 190 patients with diffuse toxic goiter combined with autoimmune thyroiditis has revealed some clinical features: a torpid course and a solid-elastic consistency of the thyroid. In 37.4% of the cases autoimmune thyroiditis was combined with a severe form of thyrotoxicosis. The combined form of diffuse toxic goiter correlated with a greater frequency of the detection of thyroid autoantibodies to thyroglobulin and microsomal antigen (in 83 and 78.3% of the patients respectively) as compared to the common form of diffuse toxic goiter (in 47.3 and 48.1%). A study of the hormonal thyroid status of 43 patients with diffuse toxic goiter combined with autoimmune thyroiditis showed that T3, T4 and TTH levels in patients with the presence of autoantibodies to thyroid antigens did not differ from the levels of these hormones in the common form of diffuse toxic goiter, and in the group of the patients with the absence of autoantibodies there was a tendency to the development of T3-toxicosis. The absence of pathognomic symptoms in combined forms of diffuse toxic goiter makes their preoperative diagnosis difficult. Interrelationship of the hormonal thyroid status and humoral antithyroid immunity was noted.
