[Postvaccinal immunity and immunological aspects of Haemophilus influenzae carrier state in children of different age groups after the administration of "Act-HIB" vaccine]. / Postvaktsinal'nyi immunitet i immunologicheskie aspekty bakterionositel'stva Haemophilus influenzae u detei razlichnykh vozrastnykh grupp posle vvedeniia vaktsiny "Akt-khib".

The article deals with H. influenzae (different serotypes) carrier state and immune response before and after the administration of the vaccine "Act-HIB" to children of different age groups. Children aged up to 1 year and over 1 year have been found to differ in the dynamics of carrier state and in the concentration of antibodies of different classes to the antigens of this infective agent, which makes it necessary to carry out their early immunization with a view to ensure their protection from H. influenzae infection.

[Diagnostic value of different laboratory methods in the diagnosis of pneumonia caused by Haemophilus influenzae type B]. / Diagnosticheskaia tsennost' razlichnykh metodov laboratornoi diagnostiki pnevmonii, obuslovlennoi Haemophilus influenzae tipa B.

Comparative analysis of the diagnostic value of different laboratory methods in the diagnosis of H. influenzae b (Hib) pneumonia in children (bacteriological method, latex agglutination, counter immunoelectrophoresis, the passive hemagglutination test and the enzyme immunoassay (EIA) was carried out. EIA proved to be the most informative method for the diagnosing Hib pneumonia. EIA makes it possible to detect specific Hib antigens in different clinical materials in 48.8% of cases, as well as high titers of antibodies to mis infective agent in 61.7% of cases. The authors propose the unified criteria of the laboratory diagnosis of Hib infection in children.

[Etiological structure of acute respiratory viral infections in children hospitalized in 1981-1999]. / Etiologicheskaia struktura ORVI u detei, gospitalizirovannykh v statsionar za 1981-1999 gg.

The role of influenza and parainfluenza viruses, respiratory syncytial viruses and adenoviruses in the etiological structure of morbidity in acute respiratory virus infections (ARVI) in children hospitalized during the 19 year period is analyzed. As the result of examination of 56,287 patients by direct immunofluorescent test, respiratory viruses were detected in 21% of cases. The seasonal character, periodicity and level of ARVI morbidity were established. According to medical records, in the 1990s ARVI took a more severe course in children than that observed in the 1980s. In addition, the data on morbidity among children regarding rotavirus infection and ARVI were found to be similar.

[New approaches in correcting disorders of higher integrative brain functions in the pharmacotherapy of arterial hypertension with propranolol]. / Novye podkhody k korrektsii narushenii vysshikh integrativnykh funktsii mozga pri farmakoterapii arterial'noi gipertenzii propranololom.

In experiments on rats it is found that propranolol in a dose of 2 mg/kg has a negative effect on higher integrative functions of the brain. Nootropics--pyracetam (200 mg/kg), AKF-94 (20 mg/kg), PIR-87-6-O (50 mg/kg) and actoprotector bemityl (40 mg/kg)--normalized orientative-trying behavior, memory, and emotionality of the animals. A possible mechanism of the drug action and prospects of their clinical application are discussed.

[Pharmacological correction of behavioral and memory disorders in rats with vasorenal arterial hypertension given propranolol]. / Farmakologicheskaia korrektsiia narushenil povedeniia i pamiati u krys s vazorenalnol arterialnol gipertenziel, poluchavshikh propranolol.

It was established that propranolol in a daily dose of 2 mg/kg causes disturbance of behavior of rats with arterial hypertension in the open field, deteriorates retention of memory traces in passive avoidance paradigm, and leads to the development of depression in the test for zoosocial interrelation. Administration of nootropic piracetam (200 kg/mg/24 h). as well as the original compounds ACP-94 (20 mg/kg/24 h) and PIR-87--6-0 (50-mg/kg/24 h) facilitates the correction of negative changes in the behavior and memory of hypertensive rats.

[A method for evaluating the zoosocial behavior of rats in psychopharmacology]. / Metodika otsenki zoosotsial'nogo povedeniia krys v psikhofarmakologii.

The method was proposed for experimental assessment of the drug psychotropic spectrum in rats under pair interaction conditions. The method was based on the recording and analysis of the main behavioral elements with a specially developed point scale. A study was done on spectra of the diazepam, amphetamine, and desipramine activity. The results of pharmacoethological analysis confirm the effectiveness of the proposed method for the assessment of psychotropic spectrum of the well known drugs (diazepam, amphetamine, desipramine), as well as new pharmacological compounds.