ABSTRACT
The influence of consumption of rations containing canned baby foods from mirror carp and Black Sea mullet on severity of system anaphylactic reaction to model food allergen in rats was studied and the level of antibodies to proteins of Black Sea mullet, mirror carp, Alaska Pollack, trout and big head was determined in serum of infants, suffering from food allergy through immune-enzyme analysis.
Subject(s)
Dietary Proteins/adverse effects , Fishes , Food Hypersensitivity/immunology , Food Preservation , Infant Food/adverse effects , Allergens/adverse effects , Allergens/immunology , Anaphylaxis/etiology , Anaphylaxis/immunology , Animal Feed , Animals , Antibody Formation/immunology , Child , Child, Preschool , Dietary Proteins/immunology , Disease Models, Animal , Edible Grain , Food Hypersensitivity/complications , Humans , Infant , Male , Rats , Rats, Wistar , VegetablesABSTRACT
The paper deals with the results of treatment of 110 patients with advanced ovarian cancer showing signs of tumor progression following polychemotherapy with two regimens which included radiotherapy. Variants of distant and contact irradiation individually-tailored to suit the types of tumor are discussed. Details of single and repeated courses of chemoradiation are presented. Such beneficial effects as longer survival and better quality of life were registered in 76%.
Subject(s)
Ovarian Neoplasms/pathology , Ovarian Neoplasms/radiotherapy , Radiotherapy, Computer-Assisted , Adult , Aged , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Female , Humans , Middle Aged , Neoplasm Staging , Ovarian Neoplasms/drug therapy , Ovarian Neoplasms/surgery , Radiotherapy Dosage , Radiotherapy, Adjuvant/methods , Retrospective Studies , Treatment OutcomeABSTRACT
The preventive and therapeutic effects of bonnecor were shown in the experiments on awake and anesthetized rats under conditions of acute myocardial ischemia. It was concluded that the relieving influence of bonnecor on the course of acute myocardial ischemia was related to its antifibrillatory and antiarrhythmic properties.
Subject(s)
Anti-Arrhythmia Agents/therapeutic use , Dibenzazepines/therapeutic use , Ventricular Fibrillation/prevention & control , Animals , Coronary Disease/complications , Coronary Disease/drug therapy , Dose-Response Relationship, Drug , Drug Evaluation, Preclinical , Male , Rats , Ventricular Fibrillation/etiologyABSTRACT
Antiarrhythmic and antifibrillation properties of bonnecor, a derivative of dibenzepin, were studied in comparison with ethmozine, quinidine and novocainamide, using various experimental arrhythmia models. Bonnecor activity was somewhat smaller than that of ethmozine, and much greater than that of quinidine and novocainamide in the mixed atrioventricular arrhythmia model simulated in aconitin-treated rats and the ventricular arrhythmia model simulated by two-degree coronary occlusion in dogs. Intravenous 1 mg/kg and oral 6 mg/kg bonnecor doses prevented ventricular fibrillation caused by acute coronary occlusion in rats, while ethmozine showed no such effect.
Subject(s)
Anti-Arrhythmia Agents/therapeutic use , Dibenzazepines/therapeutic use , Aconitine/toxicity , Animals , Anti-Arrhythmia Agents/pharmacology , Arrhythmias, Cardiac/chemically induced , Arrhythmias, Cardiac/drug therapy , Dibenzazepines/pharmacology , Dogs , Drug Evaluation, Preclinical , Guinea Pigs , Heart Rate/drug effects , In Vitro Techniques , Rabbits , Rats , Strophanthins/toxicity , Structure-Activity RelationshipABSTRACT
Calcium chloride (280 mg/kg intravenously) provokes arrhythmia, heart fibrillation and death of mice. Pretreatment with isoptin, etmozine, lidocaine, trimecaine, quinidine and novocainamide prevents rhythm disorders and animals' death. Isoptin, etmozine, lidocaine and trimecaine have been found the most effective. Atropine does not produce any protective action. The simplicity and availability of the method described enables one to apply it as a model for search of new antiarrhythmic drugs.
