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Association of Regulatory and Adaptive Status in Humans with Serotonergic Transmitter System Gene Polymorphism.

Pokrovskii, V M; Kashina, Yu V; Kiek, O V; Gumerova, O V; Gorbunova, V Yu; Abushkevich, V G; Penzhoyan, A G; Zabolotskikh, N V.

Bull Exp Biol Med ; 166(4): 487-488, 2019 Feb.

Article in English | MEDLINE | ID: mdl-30783842

ABSTRACT

The regulatory and adaptive status was determined in 202 healthy subjects by the parameters of the cardiorespiratory synchronism probe. We performed molecular-genetic analysis of polymorphic variants of the main gene of serotonin biosynthesis, tryptophan hydroxylase TPH1 (A218C polymorphism) and TPH2 (G703T polymorphism), and serotonin receptors (HTR2C and HTR2A genes). The association of the regulatory and adaptive status of a subject with the polymorphism of serotonergic mediator system genes was revealed.

Subject(s)

Polymorphism, Single Nucleotide/genetics , Pulmonary Heart Disease/genetics , Adolescent , Adult , Gene Frequency/genetics , Genetic Predisposition to Disease/genetics , Genotype , Humans , Male , Neurotransmitter Agents/metabolism , Receptor, Serotonin, 5-HT2A/genetics , Receptor, Serotonin, 5-HT2C/genetics , Serotonin/metabolism , Tryptophan Hydroxylase/genetics , Young Adult

ABSTRACT

Subject(s)

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