ABSTRACT
Biological significance of thiamin in development of experimental allergic encephalomyelitis has been elucidated. It has been shown that at the late preclinical stage of the disease thiamine metabolism is predominantly directed towards the maintaining of cellular metabolic homeostasis, whereas at the stage of clinical symptoms the anabolic process gives way to catabolic decomposition. Among tested thiamine phosphates the triphosphate ester is the most informative parameter in demyelinizing processes. Thiamine injections to immunized animals accelerate the vitamin phosphorylation depleting the reducing and energy potentials of the cell. Such thiamine antagonist as oxythiamine inhibits phosphatase reactions.
Subject(s)
Encephalomyelitis, Autoimmune, Experimental/metabolism , Thiamine Pyrophosphate/metabolism , Thiamine Triphosphate/metabolism , Thiamine/metabolism , Animals , Homeostasis/physiology , Male , Phosphorylation , Rats , Thiamine/administration & dosageABSTRACT
The authors applied a method of fluorescent ophthalmochromoscopy for the characteristics of the optic nerve in 61 patients with disseminated sclerosis. All the patients had undergone a comprehensive ophthalmological examination. A clinical characteristic is given for the initial period of disseminated sclerosis (I group of patients) and for the florid picture (II group). According to the ophthalmological examination disseminated sclerosis was suspected in 1/4 of the patients of the I group and in half of the patients of the second. The use of fluorescent ophtalmochromoscopy permitted to detect larvated lesions of the optic nerve, which by routine methods cannot be revealed. The use of this method with consideration for the period of contrasting the retinal vessles and phenomenon of the most intensive staining of the optic nerve discs permits to judge on the stage and activity of the pathological process.
Subject(s)
Multiple Sclerosis/diagnosis , Ophthalmoscopy/methods , Optic Atrophy/diagnosis , Adolescent , Adult , Female , Fluorescent Dyes , Fundus Oculi , Humans , Male , Middle Aged , Multiple Sclerosis/complications , Optic Atrophy/etiology , Retinal VesselsABSTRACT
The effect of cyclophosphamid on the development of disseminated sclerosis was studied in 85 patients. For this purpose the authors used a special scale for the assessment of neurological expressions of the disease and the remote results of treatment. The effectiveness depended mainly on the degree of severity. Satisfactory results directly following treatment were attained in patients with light and middle degrees of disseminated sclerosis. A significant regress of pathological signs on behalf of the motor (28%), sensory (37%) spheres and cranial innervation (38%) was marked. The remote results (after 6--12 months) point to the absence of development of the process. The use of cyclophosphamides was accompanied by a drop in the level of gamma-globulins in the blood serum of patients with disseminated sclerosis.
