ABSTRACT
INTRODUCTION: In recent years there has been an increasing interest in the drug treatment of benign prostatic hyperplasia (BPH) to improve the patients quality of life without surgical treatment. In this connection, phytotherapeutic drugs and biologically active dietary supplements (BADS), consisting of a combination of microelements, vitamins and plant extracts, have been increasingly used in addition to synthetic preparations. OBJECTIVE: To investigate the clinical effectiveness of dietary supplement ProstaDoz in the treatment of BPH with coexistent high-grade prostatic intraepithelial neoplasia (PIN). MATERIALS AND METHODS: The study group comprised 30 men with BPH and high-grade PIN who were diagnosed with primary biopsy and received ProstaDoz for three months. The control group included 18 patients with the same diagnosis who were treated with Tamsulosin. RESULTS: After a 3-month intake of the ProstaDoz, a statistically significant reduction was observed in symptom scores for BPH and the quality of life index by 18% (p<0.001) and 16.7% (p<0.001), respectively. The residual urine volume and total serum PSA decreased by 28.3% (p<0.001) and 46.8% (p<0.001), respectively. Unlike the control group, the rate of prostate cancer detection was 6.25 times lower in patients taking ProstaDoz, and 16% of them had lower grade PIN compared with baseline or no PIN at all. CONCLUSION: The findings suggest that using ProstaDoz in patients with BPH and high-grade PIN contributes to improving the quality of life (QoL) of patients and the regression of dysplasia.
Subject(s)
Dietary Supplements , Prostatic Hyperplasia/drug therapy , Prostatic Neoplasms/drug therapy , Quality of Life , Adult , Humans , Kallikreins/blood , Male , Middle Aged , Prostate-Specific Antigen/blood , Prostatic Hyperplasia/blood , Prostatic Hyperplasia/physiopathology , Prostatic Hyperplasia/urine , Prostatic Neoplasms/blood , Prostatic Neoplasms/physiopathology , Prostatic Neoplasms/urineABSTRACT
A mode of formation of wide fields of fast electrons at LUE-25 accelerator is proposed to expose uniformly the extended 4 cm thick biological objects. Dosimetric characteristics of the electron beams have been studied by film and ferrous-sulfate dosimeters. The potencies and limitations of using the dosimeters as a "witness" are discussed.
Subject(s)
Electrons , Particle Accelerators , Radiometry/methods , Animals , Radiometry/instrumentationABSTRACT
In order to study the early biological effects of whole-body and partial exposure of biological objects to high doses of fast electrons a simple and reliable method has been developed for the purposes of the control and correction of the dose-rates. The measurements were made of spatial distribution, in air and water, of the doses used for irradiation of the laboratory animals and cell suspensions with the indicated nonuniformity coefficients.
