[Stress-protector effect of diprim]. / Stress-protektivnoe deistvie diprima.

Diprim, a polyphenol preparation from crests of Far-Eastern grape species, influences the carbohydrate and lipid metabolism in liver of rats subjected to stress. The drug possesses antistress properties determined by the biologically active natural polyphenol derivatives. Playing the role of a buffer redox system under the stressed conditions, the polyphenol structures provide for the possibility of retaining the carbohydrate and lipid metabolism in rat liver and creating a reserve of the oxidized form of nicotinamide NAD+ coenzyme, which favors removal of the tissue hypoxia. The antioxidant properties of polyphenols from diprim preserve the phospholipid spectrum of the plasmic membranes of hepatocytes.

[Efficiency of Diprim for the restoration of the functional status of the liver after its damage by ethanol poisoning]. / Effektivnost' primeneniia rastitel'nogo preparata Diprim dlia vosstanovleniia funktsional'nogo sostoianiia pecheni posle porazheniia étilovym spirtom.

The effects of Diprim, a natural polyphenol complex isolated from Amur grapes crest, on lipid metabolism, lipid peroxidation (LPO), and antioxidative system of the liver were studied in ethanol-treated rats. Diprim injected to animals during ethanol abstinence arrested stress and thus inhibited lipolysis in fatty tissue and prevented triglyceride accumulation in the liver. Ethanol-suppressed metabolic reactions of the liver concerned with the synthesis of phospholipid fractions (phosphatidylcholine, phosphatidylethanolamine, and phosphatidylserine) were restored. Diprim promoted inhibition of LPO processes (the level of malonic dialdehyde decreased) and a pronounced glutathione-saving effect, which is largely due to its components--polyphenols which capture free radicals.

[The prevention of congenital developmental anomalies in rats]. / Profilaktika vrozhdennykh anomalii razvitiia u krys.

Preventive administration of Eleutherococcus XXX extract during prenatal and pre-embryonic periods of development prevents embryotoxic effect of subsequent treatment of pregnant rats with ethanol and sodium salicylate. Eleutherococcus abolishes embryotoxic and teratogenic effects of ethanol manifested against the background of experimental syndrome of iron deficit in pregnant females. Mechanism of its antiteratogenic action is probably based on stimulation of cell detoxification mechanisms, increase in energy potential of cells, as well as on stabilization of structural and functional state of cell membranes.