Subject(s)
Alcoholism/physiopathology , Nervous System/physiopathology , Alcoholism/pathology , Animals , Avoidance Learning/drug effects , Brain/pathology , Conditioning, Classical/drug effects , Electroencephalography , Nervous System/pathology , Rats , Self Stimulation , Stereotyped Behavior/drug effectsABSTRACT
The neurophysiological and pathomorphological characteristics of experimental alcoholism formation were studied in chronic experiments with 30 rats using a method of recording the electrical activity of different brain structures, the reaction of self-stimulation of the ventrolateral hypothalamus, amygdala and reticular formation of the midbrain, ECG, arterial pressure, conditioned reflexes, review and specialized histochemical methods. Derangements of the electrical activity of the brain, conditioned reflexes, emotional and cardiovascular reactions shared by the limbicoreticular structures and neocortex were found to be dependent on the time of alcoholization. Comparison of the neurophysiological and pathomorphological alterations in the brain seen in experimental alcoholism points to the structural and functional disorders contributing to the failure of the compensatory and adaptation mechanisms.
Subject(s)
Alcoholism/physiopathology , Brain/physiopathology , Disease Models, Animal , Ethanol/administration & dosage , Action Potentials/drug effects , Action Potentials/physiology , Alcoholism/pathology , Alcoholism/psychology , Animals , Blood Pressure/drug effects , Blood Pressure/physiology , Brain/pathology , Conditioning, Classical/drug effects , Conditioning, Classical/physiology , Dose-Response Relationship, Drug , Electroencephalography , Male , Rats , Stereotyped Behavior/drug effects , Stereotyped Behavior/physiology , Time FactorsABSTRACT
Experiments on animals demonstrated that a 3,6 and 9 month long administration of haloperidol evokes in the somatosensor zone of the cortex and subcortical nodes of rats some morphofunctional changes of the cytoplasma, nucleus, nucleoli, neurons and glial cells which are interpreted as functional-adaptive, dystrophical and compensatory. A use of haloperidol in increasing dosages (from 1 mg/kg up to 12 mg/kg) leads to an appearance of extrapyramidal disorders, a damage of the nervous system and changed forms of compensation. The most expressed changes were found in the nucleus caudatum. A long-term use of haloperidol did not exert any significant influence on the cortical function of the formation of conditioned reflexes, but there was a retardation in the fixation of new conditioned reflexes after 6 months of drug administration.
