ABSTRACT
The effects of fullerene C60 (FC60) on the level of free radical and destruction processes were studied in rats with experimental adjuvant arthritis (AA). It was shown the protective effect of FC60 during AA. The effect was accompanied by an increase of the antioxidant enzymes activity, superoxide dismutase in the liver (15.96 ± 0.38 µmol/kg x s) and in the kidneys (5.36 ± 0.27 µmol/kg x s) and catalase in the kidneys (9.56 ± 0.78 µmol/kg x s) and in the heart (2.26 ± 0.41 µmol/kg x s) in comparison to control group (43.83± 5.69%; 54.55 ± 6.18%; 11.68 ± 0.52 µmol/kg x s; 3.43 ± 0.47 µmol/kg x s; 4.77 ± 0.5 µmol/kg x s; 0.98 ± 0.12 µmol/kg x s accordingly). It was shown a protective effect of FC60 during AA directed on the depression of the destructive processes in connective tissue that was expressed through the reduction of the total collagenolitic activity level in cartilage (10.05 ± 0.06 µmol/g/min) and bone (11.21 ± 0.04 µmol/g/min) tissues, free hydroxyproline contents (1.54 ± 0.04 µg/ml) and alkaline phasphatase activity (1.24 ± 0,14 µmol/l x sec) in comparison to control group (11.91 ± 0.49 µmol/g/min; 13.19 ± 0.15 µmol/g/min; 2.25 ± 0.07 µg/ ml; 2.19 ± 0.24 µmol/l x sec accordingly). Taken together, these results accentuate the perspective of future investigations of action FC60 during rheumatoid arthritis as a feasible therapeutic agent.