1.
J Pharm Biomed Anal
; 56(3): 633-6, 2011 Nov 01.
Article
in English
| MEDLINE
| ID: mdl-21775086
ABSTRACT
Boron phenylalanine is one of the lead drug candidates in the field of Boron Neutron Capture Therapy. Its inherent low toxicity allows large doses to be administered, but this makes it important to identify, rationalise and quantify impurities. Here we report a chromatographic assay method, the conditions under which the parent compound is unstable, and the suggested degradation mechanisms.
Subject(s)
Boron Compounds/analysis , Boron Compounds/chemistry , Chromatography, High Pressure Liquid/methods , Drug Contamination , Phenylalanine/analogs & derivatives , Boron Neutron Capture Therapy/methods , Drug Stability , Phenylalanine/analysis , Phenylalanine/chemistry
2.
Org Lett
; 11(23): 5390-3, 2009 Dec 03.
Article
in English
| MEDLINE
| ID: mdl-19899747
ABSTRACT
PINDOX 8 has been identified as a chiral organocatalyst for the enantioselective ring-opening of cyclic meso-epoxides with SiCl(4) to produce chlorohydrins in up to 90% ee. The catalyst is most effective with saturated cyclic substrates containing more than seven carbon units.
