ABSTRACT
INTRODUCTION: We studied the role of human papillomavirus (HPV) typing in predicting cervical dysplasia in women with abnormal Papanicolaou (Pap) test results. STUDY DESIGN/METHODS: A university colposcopy clinic-based consecutive sample of 179 women completed a questionnaire and underwent colposcopy, HPV typing (Hybrid Capture System HPV DNA Assay II; Digene Diagnostics, Gaithersburg, MD, USA), and biopsy (if indicated). RESULTS: No severe dysplasia was observed in women with low-risk HPV or in women with negative HPV test results who had a low-grade abnormality on the Pap test. High-risk (HR) HPV was present in every case of severe dysplasia on biopsy. The cumulative odds risk for cervical dysplasia was 1.11 in HIV(+) women with low-grade squamous intraepithelial lesion on the Pap test who were older than 21 years of age and HPV-HR(+). CONCLUSIONS: In the population studied, HPV typing is a valuable adjunct to a low-grade abnormality on the Pap test in predicting the absence of cervical dysplasia on biopsy. Larger prospective population-based studies are needed to study the role of HPV as a negative predictor of disease in cervical dysplasia.
Subject(s)
Cervix Uteri/pathology , Papillomaviridae , Papillomavirus Infections/pathology , Tumor Virus Infections/pathology , Adolescent , Adult , Aged , Cervix Uteri/virology , Child , Cohort Studies , Female , HIV Infections/complications , HIV-1 , Humans , Middle Aged , Papanicolaou Test , Papillomavirus Infections/complications , Papillomavirus Infections/diagnosis , Population Surveillance , Predictive Value of Tests , Tumor Virus Infections/complications , Tumor Virus Infections/diagnosis , Vaginal SmearsABSTRACT
In recent years, incidents involving health-related complaints due to poor indoor air quality have increased dramatically. These problems have generally occurred in new or remodeled buildings. Following relocation to a new building, some employees began to experience health complaints, including upper respiratory tract irritation, headaches, fatigue, and eye irritation. A questionnaire was designed which elicited information about specific work locations, symptom experience, and timing of such symptoms. Although no causative agent(s) could be isolated, the data collected indicate that over the 5-week time period of investigation the rate and persistence of new symptoms decreased. The health complaints experienced appeared to be neither persistent nor pervasive enough to constitute an ongoing health and safety hazard at the facility. Reasons were proposed why some new and/or remodeled buildings have this type of problem while others do not.
