ABSTRACT
Male white rats divided in three groups on the basis of their behavior in the elevated plus-maze were subjected to 10-min cardiac arrest. Analysis of the results of their subsequent food and active avoidance conditioning revealed the effects of the following factors: (1) a factor of initial typological features of the higher nervous activity, (2) a factor of general brain mechanisms of postresuscitation, and (3) a factor of postresuscitation features in rats with different behaviors, which represented changes in different mechanisms of conditioned reflex performance in these animals.
Subject(s)
Conditioning, Classical , Feeding Behavior , Heart Arrest/rehabilitation , Individuality , Maze Learning , Animals , Male , Rats , ResuscitationABSTRACT
The elevated cross-shaped labyrinth test carried out on highly, moderately, and low active experimental animals revealed significant differences in the baseline density and composition of neuroglial populations of numerous formations of the brain, as well as in the early structural and functional sequels of experienced clinical death. The most pronounced postresuscitation abnormal changes were observed in highly active animals and the least marked ones were seen in moderately active animals.
Subject(s)
Behavior, Animal/physiology , Cerebral Cortex/pathology , Maze Learning , Resuscitation , Animals , Male , RatsABSTRACT
A comparative morphometric study of postresuscitation changes in the neuronal populations of the pyramidal cells from hyppocampal sector CA1 and Purkinje cells of the lateral cerebellar region in the course of postresuscitation period after 12-minute cardiac arrest in rats has shown that the changes differ in severity and pattern. In the pyramidal cells there were reversible dystrophic alterations of the neurons. Purkinje cells showed death of some neurons, this process progressed in the course of postresuscitation period. A positive effect of the peptide kyotorphin on the brain condition after resuscitation was found but its efficacy in different neuronal populations varied.
Subject(s)
Cerebellum/pathology , Hippocampus/pathology , Neurons/pathology , Resuscitation/adverse effects , Animals , Endorphins/pharmacology , Heart Arrest , Male , Neurons/drug effects , Purkinje Cells/pathology , RatsABSTRACT
A behavior examination set was used to reveal a decreased anxiety as well as increased locomotor and exploratory activities and changes in resuscitated animals undergoing different learning tests. A single injection of sandostatin--an analogue of regulatory peptide somatostatin--was found to improve the structural and functional recovery of the central nervous system after a 12-minute cardiac arrest.
Subject(s)
Behavior, Animal/drug effects , Brain/drug effects , Cardiopulmonary Resuscitation , Heart Arrest/physiopathology , Octreotide/therapeutic use , Animals , Behavior, Animal/physiology , Brain/physiopathology , Conditioning, Classical/drug effects , Conditioning, Classical/physiology , Disease Models, Animal , Escape Reaction/drug effects , Escape Reaction/physiology , Heart Arrest/therapy , Male , Maze Learning/drug effects , Maze Learning/physiology , Motor Activity/drug effects , Purkinje Cells/drug effects , Purkinje Cells/pathology , RatsABSTRACT
In experiments on rats we studied the effects of antioxidant and membrane-protecting agent mexidol and neuropeptides delta sleep-inducing peptide and oxytocin administered during resuscitation after 12-min clinical death. Individual and combination treatment with these substances accelerated recovery of the neurological status and partially or completely corrected behavioral disorders associated with changes in the emotional and motivational status. Combined administration of mexidol and oxytocin most significantly promoted postresuscitation recovery of functional activity in the central nervous system.
Subject(s)
Antioxidants/pharmacology , Brain/physiopathology , Delta Sleep-Inducing Peptide/pharmacology , Neuropeptides/pharmacology , Oxytocin/pharmacology , Picolines/pharmacology , Resuscitation , Animals , Animals, Outbred Strains , Brain/drug effects , Drug Therapy, Combination , Follow-Up Studies , RatsABSTRACT
A complex of behavioral tests revealed diminished anxiety, increased locomotor and exploratory activities, and changes in different learning tests in resuscitated animals. Mexidol alone and in combination with kyotorphin exhibited antistressogenic and nootropic activities, and led to a compensation of ischemic lesions in rats. It can be stated that a the injection of mexidol in combination with kyotorphin yielded better results due to its neuroprotective effect in the CA1 and CA4 fields of the hippocampus.
