ABSTRACT
Interleukin-2 (IL-2) production by lymphocytes of a peripheral blood (LPB) in patients with soft tissue sarcomas is considerably lower in comparison with that in donors. Autological serum had either suppressive or stimulative effect on LPB IL-2 production in the observed patients. The investigated serum affected LPB of donors in the same way. Serum of patients with soft tissue sarcomas had the same dual effect on the ability of the active drug IL-2 to proliferate human T-lymphoblasts. Moreover serum-inhibitors of production acted as IL-2 activity stimulators, while serum-stimulators of IL-2 production inhibited the mediator effects.
Subject(s)
Immune Sera/pharmacology , Interleukin-2/biosynthesis , Sarcoma/immunology , Soft Tissue Neoplasms/immunology , Blood Donors , Cells, Cultured , Humans , Interleukin-2/immunology , T-Lymphocytes/drug effects , T-Lymphocytes/immunologyABSTRACT
The data on biological properties and effects of interleukin-2, one of the main mediators of the immunity are presented. The results of its use in the tumour immunotherapy are analyzed, the used approaches and mechanisms of action of this kind of immunotherapy being estimated. The ways to increase the efficiency of interleukin-2 application in clinics are under discussion.
Subject(s)
Interleukin-2/pharmacology , Neoplasms/therapy , Animals , Humans , Interleukin-2/therapeutic use , Lymphocytes/immunology , Mice , Mice, Inbred BALB C , Neoplasms/immunology , Sarcoma/immunology , Sarcoma/therapy , Soft Tissue Neoplasms/immunology , Soft Tissue Neoplasms/therapyABSTRACT
Interleukin-2 (IL-2) production of phytohemagglutinin-stimulated peripheral blood lymphocytes (PBL) was studied in 9 healthy subjects and 19 patients with soft tissue sarcomas. Mean IL-2 production by PBL in 19 patients was significantly diminished as compared with the control. Surgery leads to an increase of IL-2 production, however, the levels observed in the control do not restore completely.
