[State of the renin-angiotensin system in children with different clinical variants of congenital adrenal cortex hyperplasia caused by 21-hydroxylase deficiency]. / Sostoianie renin-angiotenzinovoi sistemy u detei s razlichnymi klinicheskimi variantami vrozhdennoi giperplazii kory nadpochechnikov, obuslovennoi defitsitom 21-gidroksilazy.

A study was made of plasma renin activity (PRA) and serum aldosterone (A) in 52 children with congenital hyperplasia of the adrenal cortex due to 21-hydroxylase deficiency. There were 40 girls and 12 boys aged 1.5 months to 14 years. Of these, 35 had the salt-losing form (group 1), 12 were with a simple virile form (group 2), and 2 with the typical disease form (group 3). By the moment of the first examination the majority of the group 1 patients had received glucocorticoids (GC) combined with mineralocorticoids (MC), group 2 had been given GC alone, and the group 3 children had been untreated. Initially PRA in both the first and second groups was higher than in the controls. However, in group 2 that difference was insignificant. The concentration of A in group 2 noticeably exceeded that in the controls and group 1. In group 3, PRA and A did not differ from normal. After the treatment was potentiated by MC (including MC administration to the group 2 patients) there was a decline of PRA and of the A level. The changes in PRA and A did not often manifest clinically and were not associated with electrolyte disturbances. In the authors' opinion, to choose adequate doses of MC, it is necessary to examine PRA and blood A level.

[The concentration of carcinoembryonic antigen and carbohydrate antigen Ca-19-9 in the blood serum in cancerous diseases of the gastrointestinal tract]. / Kontsentratsiia rakovo-émbrional'nogo antigena i karbogidratnogo antigena Ca-19-9 v syvorotke krovi pri onkologicheskikh zabolevaniiakh zheludochno-kishechnogo trakta.

The results of comparative investigation of 266 cancer patients, 44 patients with benign G. I. tract diseases and 66 healthy subjects using 2 tumor markers (CEA and Ca-19-9) showed the diagnostic value of both methods, not exceeding 38-42%. The most informative were the data on patients with pancreatic and colorectal cancers as well as in patients with detected metastases. Significant differences in the sensitivity, specificity and diagnostic informative value between the two markers were undetectable.

[Hormonal status of diabetes mellitus patients with microcirculation disorders]. / Gormonal'nyi status u bol'nykh sakharnym diabetom s narusheniiami mikrotsirkuliatsii.

The results of the study of immunoreactive insulin (IRI) and anti-insular hormones show their correlation with hemorheological disorders in patients with diabetic angiopathies. The results obtained indicate a possible involvement of the anti-insular hormones in the development of vascular changes in diabetes mellitus.