[Possibility of inverse development of morphological changes in the rat myocardium provoked by large doses of dopamine].

It is shown that Wistar male rats keeping without medication and stressful effects for a month after administration of big doses of dopamine for two weeks does not lead to complete inverse development of heart remodeling. A decrease of the heart's mass occurs mainly because of a decrease of the right ventricle mass. The greatest changes of the extracellular matrix take place in the right ventricle: collagen level grows more noticeably, edema of the extracellular space relieves, correlations between collagen and blood vessels, cardiac hystiocytes and blood vessels increase aggravating right ventricular remodeling.