[Comparative study of different methods of determining ovalbumin in preparations of purified influenza virus]. / Sravnitel'noe izuchenie razlichnykh metodov opredeleniia oval'bumina v preparatakh ochishchennogo virusa grippa.

The degree of purity of inactivated influenza vaccines was assayed in the anaphylaxis test in guinea pigs as well as by the values of total protein and ovalbumin measured by IHA and ID tests. Quantitation of ovalbumin in vaccines by the IHA test with an antiovalbumin diagnostic preparation was found to be most informative, rapid and highly sensitive. This method may be recommended for quantitation of ovalbumin impurities in samples of purified influenza virus obtained by different methods and for different purposes.

[Characteristics of the reactogenic and immunogenic properties of killed influence vaccine purified and concentrated by the method of adsorbed chromatography on silicate sorbents]. / Kharakteristika reaktogennykh i immunogennykh svoistv ubitoi grippoznoi vaktsiny, ochishchennoi i kontsentrivoannoi metodom adsorbivovannoi khromatografii na silikatnykh sorbentakh

Reactogenic and immunogenic properties of killed influenza vaccine prepared of various strains of influenza virus by the method of sorption chromatography on sliciate sorbents were studied on small groups of volunteers; there proved to be a moderate reactogenic and a marked immunogenic activity of the experimental batches of the preparation. The dose, the concentration and the method of administration of the vaccine to obtain the immune response were determined. The indices of humoral and local immunity following a single vaccination were studied. On the basis of parenteral immunization of donors with killed influenza vaccine there were obtained experimental samples of the antinfluenza gamma-globulin with an increased specific activity.