Subject(s)
Adjuvants, Immunologic/pharmacology , Antibody-Producing Cells/drug effects , Bone Marrow/immunology , Animals , Antibody-Producing Cells/immunology , Colony-Forming Units Assay , Female , Lymphocytes/drug effects , Lymphocytes/immunology , Mice , Mice, Inbred C57BL , Mice, Inbred CBA , Swine , Time FactorsSubject(s)
Acrylic Resins/administration & dosage , Hematopoiesis/drug effects , Lymphocytes/cytology , Animals , Bone Marrow Cells , Female , Leukocyte Count , Leukocytosis/chemically induced , Leukopenia/chemically induced , Mice , Mice, Inbred C57BL , Mice, Inbred CBA , Spleen/cytology , Thymus Gland/cytology , Time FactorsSubject(s)
Pathology , Radiobiology , Animals , Bone Marrow/radiation effects , Bone Marrow Transplantation , Colony-Forming Units Assay , Humans , Intestines/radiation effects , Neoplasms, Radiation-Induced/physiopathology , Radiation Injuries/physiopathology , Radiation Injuries, Experimental/physiopathology , Radiation Tolerance , Research Design , Stress, Physiological/physiopathologyABSTRACT
Experiments on rats have shown that the blockade of M-cholinoreceptors with atropine (50,100 and 150 mg/kg) delays, while the stimulation of the M-cholinoreceptors with aceclidine (5, 10 and 15 mg/kg) intensifies the release of mature eosinophils from the bone marrow to the circulating blood. It is concluded that the peripheral M-cholinoreactive systems participate in the control of the release of the mature bone marrow eosinophils into the blood.
Subject(s)
Atropine/pharmacology , Bone Marrow Cells , Eosinophilia/physiopathology , Eosinophils/drug effects , Quinuclidines/pharmacology , Receptors, Cholinergic/drug effects , Receptors, Muscarinic/drug effects , Animals , Female , Leukocyte Count , Rats , Rats, Inbred Strains , Receptors, Muscarinic/physiologySubject(s)
Blood Physiological Phenomena , Homeostasis , Animals , Guinea Pigs , Mice , Rabbits , RatsSubject(s)
Adaptation, Physiological , Blood Physiological Phenomena , Immunity , Animals , Dogs , Guinea Pigs , Hybridization, Genetic , Mice , Mice, Inbred C57BL , Mice, Inbred CBA , Rabbits , RatsSubject(s)
Physiology/history , History, 19th Century , History, 20th Century , Russia (Pre-1917) , USSRABSTRACT
Cellular composition of the bone marrow, spleen and peripheral blood was studied after 6-hour immobilization on the back in experiments on 4 groups of (CBAxC57BL)F1 mice with varying degree of T lymphocyte deficiency (thymectomy, sham thymectomy, administration of antilymphocytic serum, B mice). The evidence obtained shows that the "lymphoid peak" recorded in the bone marrow during stress is likely to be formed at the expense of T and B lymphocyte migration from the peripheral lymphoid organs. The data have been also obtained, indicating that T lymphocytes migrating to the bone marrow during the first 6-9 hours after the exposure to stress may participate in granulocytopoiesis activation.
Subject(s)
B-Lymphocytes/immunology , Hematopoietic System/pathology , Stress, Physiological/immunology , T-Lymphocytes/immunology , Animals , Antilymphocyte Serum/pharmacology , Bone Marrow/immunology , Bone Marrow/pathology , Cell Count , Cell Movement , Hybridization, Genetic , Mice , Mice, Inbred C57BL , Mice, Inbred CBA , Spleen/pathology , Stress, Physiological/pathology , ThymectomySubject(s)
Bone Marrow/pathology , Spleen/pathology , Stress, Physiological/pathology , Animals , Blood Cells , Mice , RatsSubject(s)
DNA/radiation effects , Radiation Injuries, Experimental/etiology , Animals , Bone Marrow/physiopathology , Cell Movement , Cell Survival , DNA/biosynthesis , Dose-Response Relationship, Radiation , Mice , Parabiosis , Proteins/radiation effects , RNA/radiation effects , Radiation Injuries, Experimental/metabolism , Radiation Injuries, Experimental/physiopathology , Radiation Tolerance , Radiation, Ionizing , Radiobiology , T-Lymphocytes/transplantation , Transplantation, Homologous , Ultraviolet RaysSubject(s)
Adaptation, Physiological , Stress, Physiological , Animals , Arthritis/etiology , Endocrine System Diseases/etiology , Female , Gastrointestinal Diseases/etiology , Humans , Hypothalamus/physiopathology , Male , Mental Disorders/etiology , Nervous System Diseases/etiology , Pituitary-Adrenal System/physiopathology , Rats , Sexual Dysfunction, Physiological/etiology , Stress, Physiological/complications , Stress, Physiological/physiopathology , Stress, PsychologicalSubject(s)
Pathology/history , Physiology/history , History, 19th Century , History, 20th Century , Research , Russia (Pre-1917) , USSRABSTRACT
In experiments on rats and mice the author and his pupils showed that nonspecific effect of stimulators brought about in the first hours following the exposure migration of cells from the lymphoid organs, increase in the number of lymphoid cells in the bone marrow by 40-60%, appearance in the bone marrow of T-cells, and increase in the number of hemopoietic cells (CFU). This contributed to the activation of hemopoiesis and to development of transient hyperplasia of the bone marrow to the stage of elevated resistance of the organism. It was shown that transplantation of T-cells performed in the first hours after the sublethal irradiation hastened regeneration of hemopoiesis. All the data indicated above testify to the role of the lymphoid tissue in nonspecific resistance of the organism.
