ABSTRACT
The pharmacokinetics of dihydroquercetin (DHQ) in the forms of parent substance and a new liposomal formulation (Flamena D) have been studied in rats upon single peroral administration in a dose of 50 mg/kg. DHQ concentration after enzymatic hydrolysis in the blood plasma was determined by HPLC with UV detection. The elimination half-life of DHQ introduced in the form of Flamena D was about T(1/2) = 1.3 h. The relative bioavailability of DHQ after the administration of Flamena D amounted to 159% in comparison to that of the parent substance of DHQ.
Subject(s)
Quercetin/analogs & derivatives , Animals , Liposomes , Male , Quercetin/administration & dosage , Quercetin/pharmacokinetics , RatsABSTRACT
The space radiobiology program in Russia is aimed at obtaining fundamental data for developing radiation safety criteria. These criteria are necessary for long-term space missions. This program includes : -substantiation of radiation hazard estimation principles based on the radiation risk conception, -investigation of the radiation affection regularities under the combined influence of the spaceflight factors, -experimental investigation of the HZE-particle delayed effects and acute somatic effects induced by protons and electrons, -individual radiosensitivity investigation, -mathematic modeling of radiobiological effects , -radiobiological basis of control and forecast of radiation influence in space, -development of methods and means of an organism's radioresistance increase.
