[Secretion of immunoglobulins in malignant melanoma of the skin]. / Sekretsiia immunoglobulinov pri zlokachestvennoi melanome kozhi.

The study was concerned with the dynamics of correlations between IgA, IgM and IgG levels involved in pigmented neoplasm development in 154 cancer patients and 75 healthy subjects. The dynamics was found to represent stages of tumor development rather than changes in absolute indexes of serum immunoglobulin concentrations. The nature of changes in the structure of correlations suggested a possible switch from IgM to IgG and IgM to IgA secretion, i.e. disturbances in B-lymphocyte differentiation. Said changes were observed at a certain stage of melanoma progression, namely, during metastatic spreading.

[Use of a human embryonic antigen complex in studying the immune response in cancer patients]. / Ispol'zovanie antigennogo kompleksa iz embriona cheloveka pri izuchenii immunnogo otveta u onkologicheskikh bol'nykh.

The study was concerned with a comparison of immune response to antigen obtained from human embryonic intestine in patients with malignant and benign tumors of the breast and ovaries, cancer of the urinary bladder, cases of various inflammatory diseases and healthy controls. Application of this marker in the skin test of time-delayed hypersensitivity reaction provided a means of evaluation of tumor-associated immunological vigor. The results point to the similarity of skin reactions of time-delayed hypersensitivity in cases of mastopathy and early stages of breast cancer. Therefore, human embryonic antigen may be used as an additional criterion of assessment of immunocompetence of patients with precancerous lesions and malignant neoplasms.

[Organization of cooperative oncologic immunological research in the RSFSR]. / Organizatsiia kooperirovannykh onkoimmunologicheskikh issledovanii v RSFSR.

A number of medical establishments are conducting a joint study on Immunology of Tumors sponsored by CMEA. The study is carried out under the auspices of the P. A. Herzen Research Institute in the following directions: (1) Investigations in the diagnostic and prognostic value of immunologic tests in oncological clinic; (2) Establishment of basal immunological status of patients and its changes in relation to stages of cancer development; (3) Identification of immunological markers for tumors of different sites. This research is channeled into several programs. The success of the whole venture depends on active participation of all concerned. The results of the study will contribute to the clinical experience of application of immunological tests in examination of considerable groups of patients with tumors at different sites.

[Significance off the immunological status for the disease prognosis of oncological patients]. / Znachenie immunologicheskogo statusa dlia prognoza zabolevaniia u onkologicheskikh bol'nykh.

The importance of immune response indices in tumor patients is discussed on the basis of literature data and the author's findings. Although a correlation between clinical course of malignant disease and the patient's immunocompetence was established, the relationship of immune response indices and clinical TNM staging is not stable. Reasons are given for introducing U-criterion of immune response evaluation into TNM classification. The relationship between immune response in cancer patients and type of therapy as well as the practical importance of this parameter are discussed.

[Polysaccharide complex of human ovarian cancer studied by the microprecipitation reaction]. / Izuchenie polisakharidnogo kompleksa rakovoi opukholi iaichnikov cheloveka v reaktsii mikropretsipitatsii.

The work is concerned with studies of the polysaccharide complex (PSC) of human ovarian tumor--ovarian serous cystadenocarcinoma in the Hoigne microprecipitation reaction. It was found that PSC of ovarian tumor tissue is a serologically active preparation. However, the results of the investigation as well as the potentialities of the technic used makes it impossible to state definitely the specificity of the ovarian tumor PCS in the Hoigne microprecipitation reaction.

[Immediate tasks and the potentials of conducting immunotherapy of malignant neoplasms]. / Blizhaishie zadachi i vozmozhnosti provedeniia immunoterapii zlokachestvennykh opukholei.

This work sums up the immunological studies performed clinically and delineates the trends of further investigations in active non-specific, specific and passive immunotherapy associated with other methods of the treatment--irradiation, surgery, chemotherapy. There are offered 4 phases of the clinical study on the immunological effect on normalization of the cellular and humoral immunity responses in oncological patients: phase I--selecting of the dosage, phase II--studying of the effectiveness of immunostimulation, phase III--a detailed comparative study of new chemical drugs, phase IV--estimating the effectiveness of different schemes of immunotherapy including the combination treatment of oncological patients.

[Immunological reactivity of the body in cancer of the corpus uteri]. / K voprosu ob immunologicheskoi reaktivnosti organizma bol'nykh rakom tela matki.

Under study were the factors of antitumor immunity (RHDT, the reaction of microprecipitation, the functional activity of lymphocytes, RFC and RBT) in 104 patients with cancer of the corpus uteri. It was found that most patients show an impaired immunobiological response, manifested in higher percentage of positive results with RHDT performed with the tumor antigen, and the reaction of microprecipitation with tumor and embryonal antigens, more week RFC and RBT. Immunological indices are getting worse with the process spread and are improved following the combination therapy. The process of treatment however (surgery and radiotherapy) renders a negative effect on immune indices. Normalization of the latter is noted not earlier than 1-3 years after the treatment.

[Immunologic reactions in cervical cancer]. / Immunologicheskie reaktsii u bol'nykh rakom sheiki matki.

Under study were immunological indices--the reaction of microprecipitation (tumor and embryonal antigens) and HRDT (tumor and tuberculine antigens) in 305 patients with cancer of the uterine cervix. It was found that most patients showed impaired immune responses: an increased number of persons with specific antibodies circulating in blood serum and increased hypersensitivity of of delayed type. The percentage of positive reactions of microprecipitation and HRDT increases as the tumor spreads. The methods of combined therapy generally improve immunological indices, however, the process starts 1-3 years following the treatment.