Subject(s)
Contraceptives, Oral, Hormonal/adverse effects , Contraceptives, Oral/adverse effects , Venous Insufficiency/drug therapy , Adult , Anticoagulants/therapeutic use , Clinical Trials as Topic , Drug Evaluation , Estrogens/adverse effects , Female , Flavonoids/therapeutic use , Heptaminol/therapeutic use , Humans , Hydroxyethylrutoside/analogs & derivatives , Hydroxyethylrutoside/therapeutic use , Intrauterine Devices , Pregnancy , Progestins/adverse effects , Venous Insufficiency/chemically inducedABSTRACT
PIP: 3 parenteral progestogens (medroxyprogesterone acetate, northisterone enanthate, and dehydroxyprogesterone acetophenide with estradiol enanthate, DPA) were studied in 907 women during 14,958 cycles over a 10-year period. The findings are summarized in 9 diagrams. The frequency of the principal side effects - intermenstrual bleeding, amenorrhea, headache, dizziness and nervousness - varied with the different substances. Intermenstrual bleeding and amenorrhea were least serious using DPA. When the injections were administered at the appropriate intervals, the drugs were effective and no pregnancies occurred. After suspending the treatment, the menstrual pattern returned to normal and the endometrium was fully regenerated. To date no fetal abnormalities have been reported after discontinuing the treatment.^ieng