[Age changes in the level of pyridinoline cross-linking and ratio of soluble and insoluble collagen in human rib collagen]. / Vozrastnye izmeneniia soderzhaniia piridinolinovykh sshivok i otnosheniia rastvorimogo i nerastvorimogo kollagena v rebernom khriashche cheloveka.

The changes in the content of mature crosslinks with pyridinoline structure and soluble/insoluble collagen ratio in the costal cartilage tissue of human beings aged from 1 month to 57 years were found to be age-dependent. The effect of the pyridinoline crosslink content on the soluble/insoluble collagen ratio in human costal cartilage tissue may constitute no less than 67% of the total influence of the sum of all factors. The pronounced nonlinearity of the studied dependencies points to a possible involvement of a factor(s) other than the pyridinoline crosslink content.

[Physiological changes in pyridinoline excretion in urine depending on age and sex]. / Fiziologicheskie izmeneniia ékskretsii piridinolina s mochoi v zavisimosti ot vozrasta i pola.

Natural physiological alterations in excretion of pyridoline (total hydroxypyridoline and lysyl pyridoline) with urine were studied in children and adults depending on age (1-86 years old) and sex. Age-dependent alterations of pyridoline excretion with urine had apparently four phases: an increase, a decrease, stabilization and secondary increase. Distinct dissimilarity between men and women in the rate of pyridoline excretion was found only in the age group of 16-21 years old.

[The effect of ascorbic acid on the collagen synthesis in skin fibroblasts of children with funnel chest]. / Vliianie askorbinovoi kisloty na sintez kollagena fibroblastami iz kozhi detei s voronkoobraznoi deformatsiei grudnoi kletki.

Relative synthesis of collagen was studied in skin fibroblasts of children with funnel chest and of corresponding age children (control) in presence of ascorbic acid. In presence of ascorbic acid the rate of collagen synthesis was 2-2.4-fold lower that in corresponding controls both in proliferating and stationary cultures. At the same time, relative synthesis of collagen was quite similar both in the patient and control fibroblasts in presence of ascorbic acid. Estimation of the 14C-Hypro/14C-Pro ratio in collagens isolated from cultural media showed that there was no difference in the hydroxylation rate of collagens in control and patient fibroblasts. These data suggest that funnel chest is one of the forms of systemic connective tissue diseases, which impaired mainly the cartilages.