[Widening of possibilities of treatment of multiple sclerosis with the novel oral drug teriflunomide (aubagio)]. / Rasshirenie vozmozhnostei terapii rasseiannogo skleroza novym preparatom dlia priema vnutr' - teriflunomidom (abadzhio).

Teriflunomide is a novel oral medication for relapsing remitting multiple sclerosis (RRMS), which has demonstrated it's efficacy in relapse rate reduction. It's efficacy has been confirmed by MRI results as well. It is safe and well-tolerated, with mild and transitory side effects. Nevertheless, risk management plan should be applied to minimize and monitor possible adverse events.

[Alemtuzumab is a new drug based on monoclonal antibodies for treatment multiple sclerosis: treatment possibilities and risks(review)].

Recently published results of II and II phase clinical trials of alemtuzumab in relapsing-remitting multiple sclerosis (MS) are reviewed. This drug has an immunosuppressive mechanism of action with an anti-inflammatory effect higher than that of high-dose beta-interferon. Its neuroprotective activity and possible side-effects are discussed.

[Changes and patterns of drug resistance of mycobacterium tuberculosis in patients with pulmonary tuberculosis (by data of the microbiological laboratory of research production association "Phthysiology")]. / Dinamika i struktura lekarstvennoí ustoíchivosti mikobakterií tuberkuleza u bol'nykh legochnym tuberkulezom (Po dannym mikrobiologicheskoí laboratorii NPO "Ftiziatriia").

Changes in and patterns of drug resistance of Mycobacterium tuberculosis were analyzed in Yakutia. It was shown that in the past 5 years, there had been no rise in the total resistance; however, its patterns changed: a proportion of polyresistant strains had increased with decreases in monoresistant strains. The rate of Mycobacterium tuberculosis resistance to most antituberculous drugs was found to be growing. The pattern of resistance is varying in different areas of Yakutia.

[Characteristics of bacterial excretion in pulmonary tuberculosis patients residents of the Yakut region]. / Kharakteristika bakteriovydeleniia u bol'nykh tuberkulezom legkikh--zhitelei Iakutii.

The present state of bacilli excretion in the Yakut area and its certain social aspects are characterized, the detection rate of M. tuberculosis in pulmonary tuberculosis and the sex-age structure are subjected to analysis. Data on the primary and secondary drug resistance, type appertainance of the causative agent and the result of a disinfectant work in the infection foci have been studied in 511 patients having copious bacilli excretion.

[Bacteriologic examination for tuberculosis in subjects from a group at risk]. / Bakteriologicheskoe obsledovanie na tuberkulez lits iz grupp riska.

Laboratory methods were used to test the samples taken from 55,068 people for M. tuberculosis. Inoculation of diagnostic material for M. tuberculosis was accompanied in a number of cases by a parallel method of luminescent microscopy for the same purpose. Methods of examining the patients with non-specific lung and genitourinary diseases were developed. They consist in a preliminary step-by-step selection of diagnostic material by means of luminescent microscopy and the use of these rapid techniques, like indicator strips, making it possible to examine a great number of population within a short period of time. The expenses of step-by-step laboratory examination of risk group subjects are 4.8 times lower than those incurred with routine methods of bacteriological screening.