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Biull Eksp Biol Med ; 103(1): 54-6, 1987 Jan.
Article in Russian | MEDLINE | ID: mdl-3801652

ABSTRACT

Administration of monoamine oxidase type A inhibitor clorgyline to rats before hyperoxia prevented oxygen-induced increase in diene conjugate and Shiff's base brain and plasma levels in hyperoxia. This was due to antioxidative effect of clorgyline which resulted in stabilization of blood cellular membranes. Clorgyline had a normalizing effect on extraerythrocyte hemoglobin level, total peroxidase activity and glucose-6-phosphate dehydrogenase activity in the serum.


Subject(s)
Clorgyline/pharmacology , Erythrocyte Membrane/drug effects , Lipid Peroxides/metabolism , Oxygen/administration & dosage , Propylamines/pharmacology , Animals , Brain/drug effects , Brain/metabolism , Erythrocyte Membrane/metabolism , Glucosephosphate Dehydrogenase/blood , Hemoglobins/metabolism , Male , Oxidation-Reduction/drug effects , Peroxidases/blood , Rats , Schiff Bases/metabolism
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