ABSTRACT
Analysis of the causes of death from tuberculosis in 15 children in one of the central regions of Russia has indicated that in the past 14 years, the territorial childhood mortality rates have been 0.10-0.20 per 100,000 children. The main cause of death is tuberculous meningoencephalitis (n = 10); caseous pneumonia (n = 3), and generalized tuberculosis with severe concomitant diseases (n = 2) were less common. Tuberculous meningoencephalitis was postmortally diagnosed in 4 children who had received intensive nonspecific therapy using large doses of corticosteroid hormones. This led to the development of severe pyonecrotic meningoencephalitis with great brain edema and hemorrhoidal portions, which was early known as steroid-induced tuberculosis.
Subject(s)
Tuberculosis, Meningeal/mortality , Tuberculosis, Pulmonary/mortality , Child , Child, Preschool , Diagnosis , Humans , Infant , Male , Russia/epidemiology , Tuberculosis, Meningeal/diagnosis , Tuberculosis, Meningeal/etiology , Tuberculosis, Pulmonary/diagnosis , Tuberculosis, Pulmonary/etiologyABSTRACT
The results of study of a tuberculosis infection course in different conditions and its association with BCG revaccination are presented. The Moscow region was tentatively divided into 3 groups of regions. Children of Group 1 were not given revaccination at 7 and 12 years, those of Group 2 at 12 years and those of group 3 received revaccination according to the routine techniques at 7, 12 and 17 years. BCG revaccination withdrawal caused no increase in tuberculosis morbidity and tuberculin sensitivity. Tuberculosis detections were unassociated with the frequency of previous BCG revaccination.