[The role of renal beta-adrenoreceptors in regulating its blood supply and urine formation]. / O znachenii beta-adrenoretseptorov pochki v reguliatsii ee krovosnabzheniia i mocheobrazovatel'noi funktsii

The dog kidney blood flow and filtrative and reabsorptive functions were studied with the aid of electromagnetic flowmeter and endogenic creatinine. Beta-adrenostimulation with izadrine caused dilatation of the kidney vessels. Beta-adrenoblockade led to the opposite though insignificant effect. Beta-adrenostimulation in intact animals entailed systemic hypotension, activation of the kidney blood flow and reabsorption, decrease of filtration and diuresis. Following stabilization of arterial pressure or central inhibition of vasopressin, the beta-adrenostimulation led to the decrease in reabsorption. The data obtained seem to indicate that the direct effect of beta-adrenostimulation of the kidney channels is manifested by the inhibition of reabsorption.

[Comparative characteristics of the effect of curanthil on blood vessels of different organs]. / Sravnitel'naia kharakteristika vliianiia kurantila na sosudy raznykh organov

In experiments on dogs conducted by means of resistography Curanthil (Dipyridamol) was shown to produce a consistent fall in the resistance to the blood flow in the cardiac vessels due to their active depressor reaction. Besides, Curanthil helps a distinct fall in the resistance of the vessels of the small intestine, sceletal muscles and, to a lower degree, of the brain. These data do not support those of a selective coronary-dilating action of this drug. The reaction of the renal vessels to Curanthil was not uniform and was predominantly of a pressor nature.