ABSTRACT
The infectionized necrotic pancreatitis (NP) course, complicated by localized and diffusive peritonitis, abscess and retroperitoneal phlegmon in 86 patients, was analyzed. Severity of state of patients according to the APACHE II scale was estimated. Recommendations for application of empirical and purposeful antibacterial therapy was elaborated. Total mortality for infectionized NP with complicated course was 25.5%.
Subject(s)
Anti-Bacterial Agents/therapeutic use , Bacterial Infections/drug therapy , Bacterial Infections/microbiology , Cephalosporins/therapeutic use , Pancreatitis, Acute Necrotizing/drug therapy , Pancreatitis, Acute Necrotizing/microbiology , Abdomen/microbiology , Adolescent , Adult , Aged , Aminoglycosides , Cellulitis/drug therapy , Cellulitis/microbiology , Drug Therapy, Combination , Female , Guidelines as Topic , Humans , Male , Middle Aged , Pancreatitis, Acute Necrotizing/mortality , Peritonitis/drug therapy , Peritonitis/microbiology , Survival RateABSTRACT
During experiment in vitro and in the clinical environment in patients with the mandibula fracture there were studied up antimicrobic action of the ozonized distilled water, the ozone concentration in which had constituted 0.3 mg/l. Ozonecontaining solution was used in the form of small baths and gargles instead of conventional antiseptic solutions. While local application the pronounced antimicrobic action of ozone was noted. Additionally there was established immunomodulating action of ozone on the local immunity factors in oral cavity, demonstrated by the rise of the secretory immunoglobulin A (SIgA) level and by lowering of the serum immunoglobulins in saliva. This had witnessed the rise of resistance and lowering of expression of the mucosal inflammatory changes. In patients, to whom the conventional treatment was done, the immunologic indexes dynamics was opposite, witnessing presence in them posttraumatic immunodepression. The comparison of data, obtained in the clinic and in experiment, permits to suggest, that antimicrobic action of ozone is mostly mediated via the local immunity activization.
Subject(s)
Abscess/prevention & control , Anti-Inflammatory Agents/therapeutic use , Mandibular Fractures/therapy , Ozone/therapeutic use , Postoperative Complications/prevention & control , Humans , Treatment OutcomeSubject(s)
Anti-Infective Agents/therapeutic use , Ofloxacin/therapeutic use , Adult , Anti-Infective Agents/adverse effects , Biliary Fistula/drug therapy , Biliary Fistula/surgery , Cefazolin/therapeutic use , Cephalosporins/therapeutic use , Cholangitis/drug therapy , Cholangitis/surgery , Drug Evaluation , Drug Therapy, Combination , Gram-Negative Bacterial Infections/drug therapy , Gram-Negative Bacterial Infections/surgery , Humans , Middle Aged , Ofloxacin/adverse effectsABSTRACT
The authors have suggested a complex scheme for immunoprophylaxis of purulent-septic complications in patients with a fistula of the bile ducts, including study of the immune status, choice of the adequate immune correctors and antibiotics which act effectively on the pathogenic microflora, at individually adjusted dosages, performance of pre- and postoperative immunocorrection and immunotropic antibiotic therapy.
Subject(s)
Bile Duct Diseases/surgery , Bile Ducts, Extrahepatic/surgery , Biliary Fistula/surgery , Surgical Wound Infection/prevention & control , Adult , Aged , Antibody Formation , Bile/microbiology , Bile Duct Diseases/complications , Bile Duct Diseases/immunology , Bile Duct Diseases/microbiology , Biliary Fistula/complications , Biliary Fistula/immunology , Biliary Fistula/microbiology , Female , Humans , Immunity, Cellular , Male , Middle AgedABSTRACT
The effect of biosporin biopreparation on the agents of suppurative wound infection in the experiment on rabbits was studied. A positive effect of the preparation on healing of a suppurative wound was noted.
Subject(s)
Biological Factors/therapeutic use , Immunotherapy , Pseudomonas Infections/therapy , Staphylococcal Infections/therapy , Wound Infection/therapy , Animals , Antibiosis , Disease Models, Animal , Drug Evaluation, Preclinical , Rabbits , Time FactorsSubject(s)
Campylobacter Infections/complications , Gastritis/etiology , Peptic Ulcer/etiology , Campylobacter/isolation & purification , Campylobacter/pathogenicity , Campylobacter Infections/diagnosis , Campylobacter Infections/microbiology , Chronic Disease , Gastric Mucosa/microbiology , Gastritis/diagnosis , Gastritis/microbiology , Humans , Peptic Ulcer/diagnosis , Peptic Ulcer/microbiologySubject(s)
Cross Infection/transmission , Hospital Departments , Surgery Department, Hospital , Bacteria/isolation & purification , Carrier State/microbiology , Carrier State/transmission , Cross Infection/microbiology , Environmental Microbiology , Humans , Medical Staff, Hospital , Operating Rooms , Surgical Wound Infection/microbiology , Surgical Wound Infection/transmission , UkraineSubject(s)
Anti-Infective Agents, Local , Sutures , Animals , Drug Evaluation, Preclinical , Microbial Sensitivity Tests , Polypropylenes , Rabbits , Rats , Time FactorsABSTRACT
An analysis of 98 cases of acute postoperative pancreatitis has been made. The development of acute postoperative pancreatitis was found to be associated with the appearance of fat tissue necrosis under the influence of the activated enzymes of the pancreas The involvement of exocrinous and endocrinous structures of the pancreas into the inflammatory process was developing with progressing of the disease. Postoperative purulent pancreatitis was caused by the secondary infection of the pancreas and the pancreatic fat tissue.
