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Vopr Virusol ; 61(1): 34-9, 2016.
Article in Russian | MEDLINE | ID: mdl-27145599

ABSTRACT

Efficacy, safety, and economical aspects of treatment with abacavir, zidovudine, stavudine, and phosphazide in the schemes of antiretroviral therapy of the HIV-infected patients receiving therapy for hepatitis C virus were tested. Clinical, immunological, and virologic efficacy of treatment and dynamics of hemoglobin, thrombocytes, and alanine aminotransferase as markers of common adverse events recorded at the start of the antiviral therapy of chronic hepatitis C and after 4, 8, 12, 24, 48 weeks of the treatment were evaluated. The usage of these drugs in the schemes of antiretroviral therapy exhibited efficacy, high tolerability and safety for all HIV reverse transcriptase inhibitors.


Subject(s)
Dideoxynucleosides/therapeutic use , HIV Infections/drug therapy , Hepatitis C, Chronic/drug therapy , Organophosphonates/therapeutic use , Reverse Transcriptase Inhibitors/therapeutic use , Stavudine/therapeutic use , Zidovudine/analogs & derivatives , Zidovudine/therapeutic use , Adult , Alanine Transaminase/blood , Biomarkers/blood , Blood Platelets/drug effects , CD4-Positive T-Lymphocytes/drug effects , Cell Count , Coinfection , Dideoxynucleosides/economics , Female , Genotype , HIV Infections/blood , HIV Infections/virology , HIV-1/drug effects , HIV-1/genetics , HIV-1/growth & development , Hemoglobins/metabolism , Hepacivirus/drug effects , Hepacivirus/genetics , Hepacivirus/growth & development , Hepatitis C, Chronic/blood , Hepatitis C, Chronic/virology , Humans , Male , Organophosphonates/economics , Reverse Transcriptase Inhibitors/economics , Stavudine/economics , Zidovudine/economics
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