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1.
Rev Med Chir Soc Med Nat Iasi ; 114(1): 266-70, 2010.
Article in Romanian | MEDLINE | ID: mdl-20509314

ABSTRACT

The term of bioelectromagnetism include electromagnetosenzitive processes at the fundamental interaction of energetical fields with the matter. The alive matter has a dynamical, chemical and energetics structure, but above all, an intense informational activity. The bioelectromagnetism was gradually discovered and understood throughout history of humanity. J. Bernstein defined the cell's bioelectricity, Wagner calculated electrical conductivity and permeability of cells, starting from the Maxwell's field equations, others discovered "mitogenetic radiation" or "dark luminescence" or "ultraweak bioluminescence" and F. A. Popp founded the biophotons theory. On the other hand, Hirata and Nakatani finded points with different electrical conductivity on the surface of the skin and Voll invented the system of electro dermal testing. The practical applications of the bioelectromagnetism are the medical devices based on bioresonance, useful in diagnosis and treatment, as shown in the 17 studies (902 patients) published in 1999-2006.


Subject(s)
Electric Conductivity/history , Electrocardiography/history , Electroencephalography/history , Electromagnetic Fields , Magnetoencephalography/history , Acupuncture Points , Acupuncture Therapy/history , Electroacupuncture/history , Electromagnetic Phenomena , Evidence-Based Medicine , History, 18th Century , History, 19th Century , History, 20th Century , History, 21st Century , History, Ancient , Humans , Models, Biological , Romania
2.
Rev Med Chir Soc Med Nat Iasi ; 113(1): 103-7, 2009.
Article in Romanian | MEDLINE | ID: mdl-21495305

ABSTRACT

Congenital agamaglobulinemia is a B-cell deficiency caused by tirosin-kinase gene mutations. This article presents the case of a 2 years and 6 months old boy with a history of multiple respiratory infections, which also associates a malabsorbtion syndrome. The patient presented for symptoms of arthritis. After performing protein electrophoresis, the extremely low gamma fraction pointed out a hidden immunodeficiency. Gene analysis was performed in the Department of Pediatric Immunology of Debrecen University, Hungary and thus the final diagnosis was determined. Arthritis and respiratory symptoms improved after immunoglobulin treatment.


Subject(s)
Protein-Tyrosine Kinases/genetics , Agammaglobulinemia/complications , Agammaglobulinemia/diagnosis , Agammaglobulinemia/drug therapy , Agammaglobulinemia/genetics , Arthritis/genetics , Child, Preschool , Genetic Diseases, X-Linked/complications , Genetic Diseases, X-Linked/diagnosis , Genetic Diseases, X-Linked/drug therapy , Genetic Diseases, X-Linked/genetics , Humans , Immunoglobulins/therapeutic use , Malabsorption Syndromes/genetics , Male , Mutation , Respiratory Tract Infections/genetics , Treatment Outcome
3.
Rev Med Chir Soc Med Nat Iasi ; 112(1): 88-93, 2008.
Article in Romanian | MEDLINE | ID: mdl-18677908

ABSTRACT

UNLABELLED: The aim of the study was to evaluate the presence and etiopathogenesis of osteopenia in 41 children with Juvenile Idiopathic Arthritis (JIA). METHODS: Bone status was evaluated by quantitative ultrasound using a Sunlight Omnisense 7000s Ultrasound Bone Sonometer. Measurements were performed at the distal radius and midshaft tibia. Results were obtained as Speed of sound (SOS) and Z-score. We used standardised clinical evaluation (modified Giannini's criteria, CHAQ). ESR, Fibrinogen, serum calcium, magnesium, alkaline phosphatase, protein electrophoresis, 25-OH vitamin D (RIA) and urinary Hydroxyproline were obtained in all patients. Osteopenia was present in 15 (36.5%) patients. Statistical analysis was performed with SPSS 13.0. RESULTS: Age, sex, age at onset, disease duration, life standards and duration of corticotherapy and methotrexate treatment were not related to osteopenia in our study. The disease activity, evaluated by clinical criteria, ESR and Fibrinogen, was strongly associated with osteopenia (p<0.001). Nutritional status was an independent risk factor for osteopenia (p<0.001). Low serum calcium (p=0.034), magnesium (p=0.010), 25-OH vitamin D (p=0.091) and alkaline phosphatase (p=0.31) were more frequent in patients with osteopenia. Hydroxyproline was increased in all patients with osteopenia (p<0.001). CONCLUSIONS: Osteopenia was a frequent (36.5%) complication of JIA in our study. The disease activity and nutritional status were the most important risk factors for osteopenia. The increase of bone reabsorption was the main pathogenic mechanism of osteopenia in our study. Calcium and magnesium deficits were related to osteopenia. Decrease of bone synthesis was not associated with osteopenia in the present study.


Subject(s)
Arthritis, Juvenile/complications , Arthritis, Juvenile/diagnostic imaging , Bone Diseases, Metabolic/complications , Bone Diseases, Metabolic/diagnostic imaging , Adolescent , Alkaline Phosphatase/blood , Arthritis, Juvenile/blood , Arthritis, Juvenile/diagnosis , Arthritis, Juvenile/epidemiology , Biomarkers/blood , Bone Density , Bone Diseases, Metabolic/blood , Bone Diseases, Metabolic/diagnosis , Bone Diseases, Metabolic/epidemiology , Calcium Compounds/blood , Child , Child, Preschool , Cohort Studies , Female , Humans , Hydroxyproline/blood , Incidence , Magnesium Compounds/blood , Male , Nutritional Status , Prospective Studies , Radius/diagnostic imaging , Risk Factors , Romania/epidemiology , Tibia/diagnostic imaging , Ultrasonography , Vitamin D/analogs & derivatives , Vitamin D/blood
4.
Rev Med Chir Soc Med Nat Iasi ; 112(2): 387-92, 2008.
Article in Romanian | MEDLINE | ID: mdl-19295008

ABSTRACT

Depending on their severity, congenital or acquired, the deformations of the locomotor system affect more or less the child's mental status. Adolescence is the time when their impact is most important. When the physical, mental or functional suffering become a disability, professional and psycho-social integration problems occur. The role of the team treating such a patient is to orientate him toward a specific job corresponding to his abilities, while the social services must support him in achieving this goal. The psychotherapist is the most important person in his fight against depression and, more important, suicide.


Subject(s)
Developmental Disabilities/psychology , Disabled Persons/psychology , Musculoskeletal Abnormalities/psychology , Students , Child , Developmental Disabilities/diagnosis , Developmental Disabilities/rehabilitation , Disabled Persons/rehabilitation , Hip Dislocation, Congenital/psychology , Humans , Kyphosis/psychology , Limb Deformities, Congenital/psychology , Lordosis/psychology , Lower Extremity Deformities, Congenital/psychology , Musculoskeletal Abnormalities/diagnosis , Musculoskeletal Abnormalities/rehabilitation , Psychotherapy , Quality of Life , Scoliosis/psychology , Social Support , Spinal Diseases/psychology
5.
Rev Med Chir Soc Med Nat Iasi ; 112(3): 590-7, 2008.
Article in Romanian | MEDLINE | ID: mdl-20201237

ABSTRACT

Obesity has an increasing incidence throughout the world, inducing a complex and multisystemic pathology. The respiratory manifestations are: restrictive respiratory physiology, reduced respiratory compliance, altered ventilation/perfusion index, bronchial hyperresponsiveness. Increases in body mass index (BMI) are associated with increases in prevalence, incidence and severity of bronchial asthma. The mechanic effects of obesity remain important, but the adipocites have many influences by the hormones, leptines, cytokines and other proinflammatory agents.


Subject(s)
Asthma/epidemiology , Bronchial Hyperreactivity/epidemiology , Obesity/complications , Obesity/physiopathology , Asthma/complications , Asthma/etiology , Asthma/physiopathology , Body Mass Index , Bronchial Hyperreactivity/complications , Bronchial Hyperreactivity/etiology , Bronchial Hyperreactivity/physiopathology , Child , Forced Expiratory Volume , Gastroesophageal Reflux/etiology , Gastroesophageal Reflux/physiopathology , Humans , Incidence , Obesity/epidemiology , Overweight/complications , Prevalence , Risk Factors , Romania/epidemiology , Severity of Illness Index
6.
Rev Med Chir Soc Med Nat Iasi ; 109(1): 29-35, 2005.
Article in Romanian | MEDLINE | ID: mdl-16607823

ABSTRACT

OBJECTIVE: To evaluate bone status of asthmatic children on chronic inhaled corticoid therapy. METHODS: Bone densitometry was performed by Quantitative ultrasound (QUS) of the distal radius in 74 asthmatic children, evaluating Z-score; serum levels of 25 hydroxyvitamin D were measured in 10 cases. RESULTS: 28 of 74 children had osteopenia, defined as Z scores lower than -1. Statistic analyzes showed a significant correlation (p <0.05) of osteopenia with the duration of inhaled corticoid therapy (CSI), the absence of correlation with the dose of CSI, age, sex, severity step and duration of the disease. 25 hydroxyvitamin D was low in 8 of the 10 cases with osteopenia. Osteopenia was present in 7 children who were not under CSI, but have received multiple trials of oral corticoids for severe exacerbations. CONCLUSIONS: Osteopenia was present in 52% of children that were under inhaled corticoids for more than 12 months and it correlated with the duration of CSI, but not with the daily dose. Systemic corticoid use is a significant cause of osteopenia in asthmatic children.


Subject(s)
Adrenal Cortex Hormones/adverse effects , Anti-Inflammatory Agents/adverse effects , Asthma/metabolism , Bone Density/drug effects , Bone Diseases, Metabolic/chemically induced , Administration, Inhalation , Adolescent , Adrenal Cortex Hormones/administration & dosage , Anti-Inflammatory Agents/administration & dosage , Asthma/drug therapy , Bone Density Conservation Agents/blood , Bone Diseases, Metabolic/blood , Bone Diseases, Metabolic/diagnostic imaging , Child , Child, Preschool , Female , Humans , Male , Prospective Studies , Radius/diagnostic imaging , Ultrasonography , Vitamin D/analogs & derivatives , Vitamin D/blood
7.
Rev Med Chir Soc Med Nat Iasi ; 109(1): 140-3, 2005.
Article in Romanian | MEDLINE | ID: mdl-16607843

ABSTRACT

Authors present the first laboratory and epidemiological results which reveal the circulation in a population of protozoan Blastocystis hominis and its implication in the determinations of some gastrointestinal troubles, with fever, diarrhea and constipation, intense intestinal meteorism, associated with abdominal pain and cramps. Out of the 3106 investigated patients, 9.7% presented B. hominis as a unique etiologic agent, with an increased prevalence in adults (74.3%) and women (65.3%). Blastocystis infection with clinical manifestations or its asymptomatic form is included among emergent diseases.


Subject(s)
Blastocystis Infections/complications , Blastocystis Infections/epidemiology , Blastocystis hominis/isolation & purification , Gastrointestinal Diseases/epidemiology , Gastrointestinal Diseases/parasitology , Abdominal Pain/parasitology , Adult , Age Distribution , Albendazole/therapeutic use , Animals , Anthelmintics/therapeutic use , Blastocystis Infections/drug therapy , Child , Constipation/parasitology , Diarrhea/parasitology , Feces/parasitology , Female , Fever/parasitology , Gastrointestinal Diseases/drug therapy , Humans , Male , Prevalence , Retrospective Studies , Romania/epidemiology , Treatment Outcome
8.
Rev Med Chir Soc Med Nat Iasi ; 109(3): 497-501, 2005.
Article in Romanian | MEDLINE | ID: mdl-16607739

ABSTRACT

Authors present the results of a clinical epidemiological assessment of a retroprospective study carried out on a sample of 6717 records of children assisted for asthma in the "Sf. Maria" Emergency Clinic Hospital for Children Iasi, between 1990-2004. The epidemiological and statistical mathematics methods, both classical and computerized, highlighted an increase in the incidence and prevalence values in 2000, as a consequence of National Program for Asthma. For the entire period of study, the morbidity values increased in the cold and transit season, due to the acute respiratory infections, and in the warm season, by the atmospheric pollen. The anatomic-physiological peculiarities of the respiratory tubes explained the higher prevalence of asthma in males aged until 10 years old. Asthma had an increased incidence in the age groups of 4-6 years old (28.21%) and 7-9 (30.42%), as a result of the entrance in collectivities where there is a high risk for acute respiratory infections. A lower prevalence of asthma in young-age groups was explained by a difficult diagnosis. The results above-mentioned can offer orientations for the clinical epidemiological surveillance programs of asthma.


Subject(s)
Asthma/epidemiology , Emergency Service, Hospital/statistics & numerical data , Hospitals, Pediatric/statistics & numerical data , Adolescent , Child , Child, Preschool , Female , Hospitals, University , Humans , Incidence , Infant , Male , Medical Records , Prevalence , Prospective Studies , Retrospective Studies , Romania/epidemiology
9.
Rev Med Chir Soc Med Nat Iasi ; 108(3): 491-6, 2004.
Article in Romanian | MEDLINE | ID: mdl-15832961

ABSTRACT

Bronchial asthma becomes one of the most frequent respiratory diseases of the childhood. Progresses of the last decade did not interfere with long term prognosis of the disease. New therapeutic researches try to stop the chronic inflammatory respiratory mechanism: cytokines, leukotrienes, transcription factors, IgE. Some of the new drugs are still only experimental--cytokines antagonists, transcription factors inhibitors, adhesin antibodies, other close to clinical use--new corticosteroids, leukotrienes antagonists, anti IgE antibodies. The new therapeutics methods will be used among the classical drugs and will improve the quality of the patients' life.


Subject(s)
Anti-Asthmatic Agents , Asthma/drug therapy , Anti-Asthmatic Agents/pharmacology , Anti-Asthmatic Agents/therapeutic use , Anti-Inflammatory Agents/therapeutic use , Asthma/metabolism , Chemokines/antagonists & inhibitors , Chemokines/therapeutic use , Cytokines/antagonists & inhibitors , Cytokines/therapeutic use , Drug Therapy, Combination , Humans , Leukotrienes/metabolism , Quality of Life , Selectins/metabolism
10.
Rev Med Chir Soc Med Nat Iasi ; 108(4): 753-7, 2004.
Article in Romanian | MEDLINE | ID: mdl-16004211

ABSTRACT

The relationship between bronchial asthma (BA) and gastro-esophageal reflux (GER) impose to study by frequency, reciprocally prognosis and therapeutics difficulty. Coexistence of both diseases is suggested by presence of asthmatics symptoms in non-atopic patients, difficult control and resistance of the specific treatment of asthma disease, worsening of respiratory symptoms in circumstances which favored GER. Pathogenetic relationship between BA and GER in children is the result of the associations- digestive particularity and: esophago-bronchial neurogenic mechanism produced by micro-aspiration , genetic or obtained inflammations development by commune Th2 mediators, medications effects. Classical treatments (H2-inhibitors, prokinetics agents, inhibitors of protonic pumps) is associated of the antiasthmatics "controller" therapy and in the future, anti-cytokine and anti-receptor therapy.


Subject(s)
Asthma/physiopathology , Asthma/therapy , Gastroesophageal Reflux/physiopathology , Gastroesophageal Reflux/therapy , Asthma/complications , Child , Child, Preschool , Cholinergic Antagonists/therapeutic use , Drug Therapy, Combination , Enzyme Inhibitors/therapeutic use , Fundoplication , GABA Agonists/therapeutic use , Gastroesophageal Reflux/complications , Histamine H2 Antagonists/therapeutic use , Humans , Serotonin Receptor Agonists/therapeutic use
11.
Rev Med Chir Soc Med Nat Iasi ; 108(4): 871-4, 2004.
Article in Romanian | MEDLINE | ID: mdl-16004233

ABSTRACT

The Authors present the results of a multidisciplinary study carried out on a sample of 103 children comprised in a programme of vaccination against Streptococcus pneumoniae infections, in order to avoid the worsening of their asthma. In the nasopharyngeal exudate of 39 children, we detected the presence of S. pneumoniae strains of serotypes 6, 8, 14, and 19 and their absence after vaccination with PNEUMO 23. This was followed by a significant decrease in the incidence of pneumococcal infections and also by the reduction in the frequency of crises and severity of the disease.


Subject(s)
Asthma/epidemiology , Asthma/microbiology , Pneumococcal Infections/microbiology , Pneumococcal Vaccines/administration & dosage , Streptococcus pneumoniae/isolation & purification , Case-Control Studies , Child , Child, Preschool , Humans , Incidence , Pneumococcal Infections/epidemiology , Pneumococcal Infections/prevention & control , Romania/epidemiology , Severity of Illness Index
12.
Rev Med Chir Soc Med Nat Iasi ; 107(4): 886-8, 2003.
Article in Romanian | MEDLINE | ID: mdl-14756040

ABSTRACT

The hemangioendothelium is a vascular tumor rarely seen in the pediatric practice. This case underlines the difficulty that lies in establishing a differential diagnosis with a localized adenopathy when this vascular tumor is developing inside a ganglionic region. The surgical treatment followed by interferon therapy determined a favorable evolution in this case because the hemangioendothelium is a vascular borderline tumor. Still, there are cases that recur, metastasize and have an evolution towards death.


Subject(s)
Head and Neck Neoplasms/diagnosis , Hemangioendothelioma/diagnosis , Antineoplastic Agents/therapeutic use , Child , Diagnosis, Differential , Head and Neck Neoplasms/drug therapy , Head and Neck Neoplasms/surgery , Hemangioendothelioma/drug therapy , Hemangioendothelioma/surgery , Humans , Interferons/therapeutic use , Male , Treatment Outcome
13.
Rev Med Chir Soc Med Nat Iasi ; 107(2): 324-30, 2002.
Article in Romanian | MEDLINE | ID: mdl-12638284

ABSTRACT

The individualized, retrospective study of 14 children with SLE (4-16 years) pointed out a series of clinical and age dependent evolutive characteristics. Below the age of 10 years old (lot 1:2 boys and 4 girls), SLE started as a prolonged fever syndrome (5-16 weeks) in the majority of cases; for 2 children the severe poliarthritis resistant to the AINS therapy is associated with the durable absence of the antinuclear seric antibody (ANA). For the same age group a high frequency of neurological manifestations (5/6 cases) was noticed. After the age of 10 years old (lot II: 8 girls) the symptoms incidence at debut is close to the one of the adult, the cutanat and renal manifestations in evolution were dominant (7/8 cases). The 7 months absence of ANA characterises a case that started with hepatomegaly, severe neurological and physiological manifestations and microscopic hematuria. The follow-up lasted until the age of 16 years old; the patients were clinically tested for severe renal complication. The correct application of the classical criteria of diagnostic (ARA, 1982), and in the last few years the application of the ponderat score (Mayer, 1998), allows us to establish an early diagnostic and a rapid evaluation of a relapse, therefore influencing the treatment.


Subject(s)
Lupus Erythematosus, Systemic/diagnosis , Adolescent , Antibodies, Antinuclear/blood , Arthritis/etiology , Child , Child, Preschool , Female , Fever/etiology , Hematuria/etiology , Humans , Lupus Erythematosus, Systemic/blood , Male , Retrospective Studies
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