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Bioorg Med Chem Lett ; 21(21): 6293-6, 2011 Nov 01.
Article in English | MEDLINE | ID: mdl-21945203

ABSTRACT

The design and synthesis of dehydroxymethylepoxyquinomicin (DHMEQ) derivatives were carried out to investigate the intracellular targets. The synthetic biotin probe exhibited membrane permeability and combined selectively with the target protein p65.


Subject(s)
Benzamides/pharmacology , Biotin/chemistry , Cyclohexanones/pharmacology , NF-kappa B/drug effects , Benzamides/chemistry , Cyclohexanones/chemistry , Humans , Structure-Activity Relationship
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