[Study of the HLA and IgE systems in healthy persons and in patients with allergies of the respiratory tract]. / Issledovanie sistemy HLA i IgE u zdorovykh lits i bol'nykh allergozami dykhatel'nykh putei.

The purpose of the paper is to study the association of HLA-antigens and serum levels of IgE in healthy persons and patients with allergic diseases of the respiratory tracts in Georgian population. Research showed the association of the HLA-system and genes controlling serum levels of IgE. The association of comparatively low levels of IgE with antigens HLA-A11, B35, Cw4, and of a raised level with B7 and Cw2 antigens was established in healthy subjects. Healthy persons carrying antigen B7 and residents of the endemic zone of ragweed spreading formed a group at high risk of developing hyper-IgE response and ragweed pollinosis. Production of specific IgE antibodies was clearly correlated with certain HLA-antigens whereas the association of the HLA-system with total IgE levels was less marked and was revealed at comparatively low (less than 213.55 kU/l) or at significantly raised (over 433.41 kU/l) levels of total IgE. Development of hyper-IgE response (over 1000 kU/l) was associated with HLA-A3 (RR = 2.2; delta = 0.21).