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1.
Respir Med Res ; 82: 100966, 2022 Nov.
Article in English | MEDLINE | ID: mdl-36274550

ABSTRACT

Optic neuritis with CRMP-5 IgG is a paraneoplastic inflammation of the optic nerve associated with lung cancer, mostly small-cell lung cancer. We present the case of a patient with lung adenocarcinoma who developed progressive bilateral visual loss a few months after immune-chemotherapy with pembrolizumab and after Covid-19 vaccination. Positive CRMP-5 IgG were detected in blood sample and complete work-up - including brain MRI - did not show any progression. High dose systemic corticoids were administered with transient improving, followed by intravenous immunoglobulins, methotrexate and rituximab but despite negativization of CRMP-5 IgG, the patient had a progressive visual loss.


Subject(s)
Adenocarcinoma of Lung , COVID-19 , Lung Neoplasms , Optic Neuritis , Humans , COVID-19 Vaccines , Microtubule-Associated Proteins , Nerve Tissue Proteins , Hydrolases , Optic Neuritis/etiology , Optic Neuritis/complications , Adenocarcinoma of Lung/complications , Adenocarcinoma of Lung/diagnosis , Lung Neoplasms/complications , Lung Neoplasms/diagnosis , Immunoglobulin G
2.
IDCases ; 26: e01272, 2021.
Article in English | MEDLINE | ID: mdl-34584843

ABSTRACT

Toxic Shock Syndrome (TSS) is a very rare and severe complication of Staphylococcus aureus infections. However, bacteremia is very uncommon in this disease. We present here the case of a healthy 15-year old boy who presented septic shock and diffuse exanthema four hours after eating in a fast food restaurant. Blood cultures were positive for a TSST-1 producing Staphylococcus aureus. The patient was treated with antibiotics and fully recovered.

3.
Support Care Cancer ; 29(11): 6271-6278, 2021 Nov.
Article in English | MEDLINE | ID: mdl-33851236

ABSTRACT

BACKGROUND: Immunocompromised cancer patients are presumed to be at high risk of developing COVID-19 infection. Predisposing factors to contracting COVID-19 and to severe outcomes have been described in registries but were not compared between solid tumors and hematological malignancies. METHOD: This retrospective single oncologic center study included adults with solid tumors or hematological malignancies referred to testing by naso-pharyngeal swab for a SARS-CoV-2 RT-PCR from March 10 to May 18, 2020. RESULTS: A total of 212 patients were included in the study. Forty-five (21%) were tested positive with SARS-CoV-2. The univariate analysis with positive SARS-CoV-2 PCR as a dependent variable reveals significant odds ratios (ORs) for age-with a mean of 62.5 years-(OR: 1.05, 95% CI: 1.02-1.08), performance status ≥2 (OR: 2.38, 95% CI: 1.22-4.70), inpatient status (OR: 2.36, 95%CI: 1.11-4.91), and hematological malignancies (OR: 2.48, 95% CI: 1.23-4.96). In contrast, OR for solid tumors reveals a negative association (OR: 0.40, 95% CI: 0.20-0.81). When integrating severe outcome (ICU admission or COVID-19-related death) as a dependent variable, the univariate logistic regression model shows significant ORs for pre-existing lymphopenia (OR: 4.0, 95% CI: 1.17-15.04), hematological malignancies (OR: 3.73, 95% CI: 1.09-13.80), and a negative association for solid tumors (OR: 0.27; 95% CI: 0.07-0.92). CONCLUSION: In patients referred for SARS-CoV-2 testing, hematological malignancies were associated with a higher risk of COVID-19 infection and severe outcomes. Other factors were age and inpatient status.


Subject(s)
COVID-19 , Hematologic Neoplasms , Neoplasms , Adult , COVID-19 Testing , Hematologic Neoplasms/epidemiology , Humans , Middle Aged , Neoplasms/epidemiology , Retrospective Studies , SARS-CoV-2
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