ABSTRACT
We represent an organization of transfusionnel advice at a regional level and we develop arguments and stages having allowed us to lead to this choice. This target was reached in two stages, which took place over 3 years. The regional transfusionnel advice leans on three fundamental points: a planned permanent organization, skilled and formed actors as well as adapted tools. Tending to a homogeneous organization between every blood bank center seems to be coherent towards the current configuration of blood donation in France.
Subject(s)
Blood Banks/organization & administration , Blood Transfusion , Consultants , Counseling/organization & administration , Blood Component Transfusion , Blood Preservation/methods , Blood Preservation/standards , Decision Making , France , Hospitals, University/organization & administration , Humans , Prescriptions , Program Evaluation , TransportationSubject(s)
Blood Transfusion , Graft Survival , HLA Antigens/immunology , Kidney Transplantation/physiology , Adult , Cadaver , Drug Therapy, Combination , Female , Follow-Up Studies , Graft Rejection/diagnosis , Graft Rejection/epidemiology , Histocompatibility Testing , Humans , Immunosuppression Therapy/methods , Immunosuppressive Agents/therapeutic use , Isoantibodies/blood , Kidney Transplantation/immunology , Male , Middle Aged , Regression Analysis , Time Factors , Tissue Donors , Transplantation, HomologousABSTRACT
Chromosome anomalies, structural and/or numerical changes are present in about 50% of acute non lymphoïd leukemia (ANLL). They are non-random: chromosome 8, 7, 5 and 11 being more frequently involved. Correlations between chromosomal anomalies and type of proliferation have been established: translocation t (8;21) and acute myeloblastic leukemia M2; translocation t (15;17) and acute promyelocytic leukemia M3; structural anomalies of chromosome 11 long arm and acute monoblastic leukemia M5. A relationship between prognosis and leukemic karyotype has been found. Median survival is generally longer in patients with normal karyotypes. Future studies may correlate chromosome anomalies and metabolic changes with the help of progress in gene mapping. A better knowledge will provide not only a better therapy but also a better understanding of the leukemic process.
Subject(s)
Leukemia, Myeloid, Acute/genetics , Leukemia/genetics , Chromosome Aberrations , Chromosome Disorders , Humans , Prognosis , Translocation, GeneticABSTRACT
Chromosome anomalies, structural and/or numerical changes are present in about 50% of acute non lymphoid leukemia (ANLL). They are non-random: chromosome 8, 7, 5 and 11 being more frequently involved. Correlations between chromosomal anomalies and type of proliferation have been established: translocation t (8;21) and acute myeloblastic leukemia M2; translocation t (15;17) and acute promyelocytic leukemia M3; structural anomalies of chromosome 11 long arm and acute monoblastic leukemia M5. A relationship between prognosis and leukemic karyotype has been found. Median survival is generally longer in patients with normal karyotypes. Future studies may correlate chromosome anomalies and metabolic changes with the help of progress in gene mapping. A better knowledge will provide not only a better therapy but also a better understanding of the leukemic process.
